hVEGFR2
Nomenclature
C57BL/6Smoc-Kdrtm2(hKDR) Smoc
Cat. NO.
NM-HU-00098
Strain State
Embryo cryopreservation
Gene Summary
Gene Symbol
KDR
Model Description
Validation Data
Figure 1. Expression of mouse KDR and human KDR in C57BL/6 wild type mice and KDR-HU homozygous mice.
Figure 2：In vivo validation of anti-tumor efficacy in a B16F1 tumor-bearing model of humanized KDR mice. The results showed: The drugs targeting human KDR were associated with a very significant anti-tumor, demonstrating that the humanized KDR mice are a good in vivo model for validating the efficacy of drugs targeting human KDR.
Figure 3：In vivo validation of anti-tumor efficacy in a MC38 tumor-bearing model of humanized KDR mice. The results showed: The drugs targeting human KDR were associated with a very significant anti-tumor.
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
Learn moreSMOC’s Annual Progress and Advances in Preclinical immuno-Oncology Research: The workshop is designed as a forum for ideas and opinions exchange on how to decrease the rate of clinical failures in oncology and immuno-oncology.
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