In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.
|
|
||
|
|
Strain Name：C57BL/6Smoc-Abcb1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-205105
|
|
|
|
||
|
|
Strain Name：C57BL/6Smoc-Abcb11em1(flox)Smoc
Strain State：Developing | Cat. NO.：NM-CKO-233981
|
|
|
|
||
|
|
||
|
|
Strain Name：C57BL/6Smoc-Abcb5em1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-2106122
|
|
|
|
||
|
|
||
|
|
