hCD3EDG
Nomenclature
C57BL/6JSmo-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)Smoc
Cat. NO.
NM-HU-220120
Strain State
Repository Live
Model Description
Validation Data
Fig.1 Detection of human CD3E,CD3D,CD3G on T cell surface in HO hCD3EDG mice.
Fig.2 Lymphocyte Lineage Characterization in Blood in Homozygous hCD3EDG Mice.
Fig.3 In vivo AICD and irAE Assessment of Bispecific T Cell Engager Antibodies in Homzygous hCD3EDG Mice.
Homozygous hCD3EDG mice were engrafted with MC38-hEpCAM to evaluate the AICD and irAE of OKT3 and anti-CD3×EpCAM bispecific antibody in vivo.
Fig.4 In Vivo Response with Bispecific T Cell Engager Antibodies in Homozygous hCD3EDG Mice.
Homozygous hCD3EDG mice were engrafted with MC38-hCLDN18.2 to eveluate the in vivo efficacy of anti-CD3×Claudin18.2 bispecific antibody.
Fig.5 In vivo AICD and irAE Assessment of CD3 Bispecific Antibody in homozygous hCD3EDG Mice.
The anti-tumor response of anti-mPD-1 was evaluated in homozygous hCD3EDG mice bearing MC38 syngeneic tumor model.
Fig.6 In vivo AICD and irAE Assessment of CD3 Bispecific Antibody with Homozgyous hCD3EDG Mice.
Homozygous hCD3EDG mice were engrafted with MC38-hEpCAM to eveluate the AICD and irAE of anti-CD3×EpCAM bispecific antibody at low and high dose levels in vivo.
Fig.7 In Vivo Response with Bispecific T Cell Engager Antibodies.
You may also like
Tamoxifen诱导Cre-ERT2小鼠 使用指南
Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
Learn moreCre-lox系统介绍及使用汇总
你一定听说过Cre-lox重组系统，无论你是否直接进行过基因操作。由于Cre-lox系统具有操作简单、重组率高的优点，如今已经成为体内外遗传操作的强有力工具。利用Cre-lox系统，可以在特定细胞、组织或整个生物体，甚至在特定时间点敲除或表达某个基因，实现对特定基因的时空特异性操作，这对基因功能的研究和人类疾病动物模型的建立都具有深刻影响。
Learn more
