hCD40/h4-1BB(2)
Nomenclature
C57BL/6JSmo-Cd40tm1(hCD40)Tnfrsf9tm2(TNFRSF9)Smoc
Cat. NO.
NM-HU-200256
Strain State
Embryo cryopreservation
Model Description
hCD40(NM-HU-00076)was crossed with h4-1BB(NM-HU-190077) to generate hCD40/h4-1BB(2) mice.
Research Application：Immunotherapy,drug screening
*Literature published using this strain should indicate: hCD40/h4-1BB(2) mice (Cat. NO. NM-HU-200256) were purchased from Shanghai Model Organisms Center, Inc..
Validation Data
Fig1. In vivo validation of double humanized CD40&4-1BB mice. Double humanized mice were inoculated with B16F10 cells, and randomly assigned to different groups (n=6) when the tumor grew to a volume of 80 mm3. A combinatorial treatment of anti-CD40 and anti-4-1BB inhibited tumor growth (top) without affecting the animal body weight (Bottom).
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