hCD20(2)

Nomenclature

C57BL/6Smoc-Ms4a1tm3(hCD20)Smoc

Cat. NO.

NM-HU-200114

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Ms4a1

Synonyms

Cd20; Ly-44; Ms4a2; AA960661

NCBI ID

12482

MGI ID

88321

Ensembl ID

ENSMUSG00000024673

Pubmed

Ms4a1

Human Ortholog

MS4A1

Model Description

Extracellular and transmembrane region of the endogenous mouse Ms4a1 gene was replaced by corresponding region of human CD20 gene. While hCD20(Stock No.NM-HU-190068) mice function similarly to hCD20(2) mice,for more detailed information please contact our technical advisor.
Research Application：Immune-related; drug screening

Validation Data

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Fig1. Detection of hCD20 expression on mCD19+ B cells in blood in hCD20 knockin mice.

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Fig2. Rituximab can bind to lymphocytes of hCD20 knockin mice.

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Fig.3 In vivo B cells depletion in hCD20 knockin mice. (In cooperation with a third party)

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