hPD-1/hPD-L1

Fig1. The expression of human PD-1 and PD-L1 in double humanized PD-1&PD-L1 mice was confirmed by FACS.

Efficacy study

Fig2. In vivo validation of double humanized PD-1&PD-L1 mice. Double humanized mice were inoculated with MC38 cells, and randomly assigned to different groups (n=8) when the tumor grew to a volume of 100 mm3. A combinatorial treatment of anti-PD-L1 and anti-PD-1 demonstrated a noticeable efficacy improvement compared to the same dose of single agent (top) without affecting the animal body weight (Bottom).