hCD3E

Nomenclature

C57BL/6JSmo-Cd3etm1(hCD3E) Smoc

Cat. NO.

NM-HU-00114

Strain State

Repository Live

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Gene Summary

Gene Symbol
CD3E

Synonyms

CD3; T3e; AI504783; CD3epsilon

NCBI ID

12501

MGI ID

88332

Ensembl ID

ENSMUSG00000032093

Pubmed

CD3E

Human Ortholog

CD3E

Model Description

The endogenous mouse Cd3e gene was replaced by human CD3E gene . While hCD3E(2)(Stock No.NM-HU-210023) mice function similarly to hCD3E mice,for more detailed information please contact our technical advisor.
Research Application：Immunotherapy,cancer research,drug screening

Validation Data

CD3E-1.png

Fig1. The expression of human CD3E in the peripheral blood cells derived from heterozygous or homozygous humanized mice was confirmed by FACS. 

CD3E-2.png

Fig2. Detection of T cell subsets in the peripheral blood cells derived from heterozygous or homozygous CD3E humanized mice.

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Fig3. Detection of B and NK cells in the peripheral blood cells derived from heterozygous or homozygous CD3E humanized mice.

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Fig4. In vitro T cell activation with heterozygous or homozygous CD3E humanized mice.

CD3E-Fig5.png

Fig5. Cytokine analysis of anti-human CD3E antibody treated hCD3E mice. 

The data is provided by Crownbio.

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