Prl-IRES-CreERT2

Nomenclature

C57BL/6Smoc-Prlem1(IRES-CreERT2)Smoc

Cat. NO.

NM-KI-200170

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Prl

Synonyms

Gha1; Prl1a1; AV290867

NCBI ID

19109

MGI ID

97762

Ensembl ID

ENSMUSG00000021342

Pubmed

Prl

Human Ortholog

PRL

Model Description

A IRES-CreERT2 expression cassette was knocked into the Prl gene stop codon site. Prolactin (PRL) is a hormone synthesized and secreted by lactotroph cells in the anterior pituitary gland. PRL is responsible for lactogenesis and other processes associated with it. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre.
Research Application：Cre recombinase tool

Validation Data

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Fig. 1 CreERT2-mediated recombination in the pituitary gland of PrlCreERT2/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the anterior pituitary gland of PrlCreERT2/+; Rosa26tdTomato/+ mouse. Some leakiness were detected prior to tamoxifen exposure.

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Fig. 2 Detection of tdTomato(red) in various tissues of PrlCreERT2/+; Rosa26tdTomato/+ mice. Tdtomato is expressed in the anterior pituitary gland and in individual cells of the thymus and brain. Tdtomato expression can not be observed in the retina, brown fat, lung, liver, stomach, salivary gland, kidney, pancreas, intestine, colon, ovary and muscle.(For more detailed information please contact our technical advisor.)


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