Overcome the Hurdle to Generate High Affinity and Diversity Antibodies to Self- or High Homology Antigens
Registration link:
https://us06web.zoom.us/webinar/register/WN_zp48kyBhSH2rHpm_adFNIw
Date:
- Thursday, Aug 28th, 2024; 2:00 pm EDT or 11:00 am PDT
Webinar Highlights:
This webinar will explore various methods for generating monoclonal antibodies, emphasizing the challenges of producing high-affinity antibodies to self or highly homologous antigens. Traditional methods, like in vitro screening and hybridoma-derived antibodies post-immunization, are cost-effective but struggle with these targets. Alternative approaches, such as fusion expression with T cell epitopes and autoimmune mouse models, have had limited success. Immunizing genetic knockout mice with the target protein is another strategy, though its application is limited by the availability of knockout animals. Genobiotx offers a solution with its extensive knockout mouse strains and technology, enabling the production of high-affinity antibodies within six months.
Meet Our Speaker:
Dongxiao Feng, Vice President of GenoBioTX, he got his PhD from Chinese Academy of Medical Sciences and has postdoctral experiences at Oxford University and University of California, San Francisco. Dr. Feng has 30 years experiences in monoclonal antibody development using hydridoma, phage and yeast display methods. He also led the development of the second generation of Humab mice at BMS and a fully human antibody transgenic mouse platform in China, 2 antibody drugs developed by Dr. Feng's team have been approved in China and at phase III clinical stage in US. He joined Genobiotx 2 years ago as the vice president of business development.
About GenoBioTX
GenoBioTX provides comprehensive animal modeling services, ranging from model construction to preclinical in vitro and in vivo assays, based on the combination of versatile technical platforms and experienced scientist.
Contact us
Website: www.genobiotx.com
Email: info@genobiotx.com
Address: 10410 Corporate Dr., Sugar Land, TX, 77478, USA
You may also like
Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
Learn more你一定听说过Cre-lox重组系统，无论你是否直接进行过基因操作。由于Cre-lox系统具有操作简单、重组率高的优点，如今已经成为体内外遗传操作的强有力工具。利用Cre-lox系统，可以在特定细胞、组织或整个生物体，甚至在特定时间点敲除或表达某个基因，实现对特定基因的时空特异性操作，这对基因功能的研究和人类疾病动物模型的建立都具有深刻影响。
Learn more
