hMC4R-R165W

Nomenclature

C57BL/6Smoc-Mc4rtm1(hMC4R-R165W)Smoc

Cat. NO.

NM-HU-233884

Strain State

Repository Live

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Gene Summary

Gene Symbol
Mc4r

Synonyms

Pkcp; Mc4-r

NCBI ID

17202

MGI ID

99457

Ensembl ID

ENSMUSG00000047259

Pubmed

Mc4r

Human Ortholog

MC4R

Model Description

The endogenous mouse Mc4r gene was replaced by hMC4R-R165W.

Validation Data

image.png

Fig.1 Detection of MC4R expression in brain by RT-PCR. 

Wild type: only one band at 264 bp with primers F1/R1(mMc4r); 

Homozygous: only one band at 628 bp with primers F2/R2(hMC4R). 

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.2 Detection of human MC4R expression in brain in hMC4R-R165W mice by WB. 

Abbr. M, marker; WT, wild type; HO, Homozygous; PC, positive control, HepG2 cells.

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