hMC4R

Nomenclature

C57BL/6Smoc-Mc4rtm1(hMC4R)Smoc

Cat. NO.

NM-HU-233876

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Mc4r

Synonyms

Pkcp; Mc4-r

NCBI ID

17202

MGI ID

99457

Ensembl ID

ENSMUSG00000047259

Pubmed

Mc4r

Human Ortholog

MC4R

Model Description

The endogenous mouse Mc4r gene was replaced by human MC4R gene.

Validation Data

image.png

Fig.1 Detection of MC4R expression in brain by RT-PCR. 

Wild type: only one band at 264 bp with primers F1/R1(mMc4r);

Homozygous: only one band at 342 bp with primers F2/R2(hMC4R).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.2 Detection of human MC4R expression in brain in hMC4R mice by WB. 

Abbr. M, marker; WT, wild type; HO, Homozygous.

Note. The anti-human MC4R antibody cross-reacted with mouse MC4R and humanized MC4R.

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