pAlb-hLPA-Tg(V2)

Nomenclature

C57BL/6JSmo-Tgtn(pAlb-hLPA-3’UTR-pA)1Smoc

Cat. NO.

NM-TG-231782

Strain State

Repository Live

Export PDF

Model Description

These transgenic strains harbor pAlb-hLPA-3’UTR-pA expression cassettes.

Validation Data

image.png

Fig.1 Detection of hLPA expression in serum by ELISA. 

Abbr. WT, wild type.

image.png

Fig.2 Detection of serum hLPA protein level (A) and inhibiton ratio (B) after single dose of test compound (male, n=5/group). (Data from a collaborator)

 image.png

Fig.3 Detection of human LPA inhibition by Lepodisiran. Lepodisiran did not induce significant changes in body weight of the pAlb-hLPA-Tg(V2) mice. 6-8-week-old, male pAlb-hLPA-Tg(V2) mice were assigned to four groups for saline or Leposiran (n=5 in each group). Following a single subcutaneous dose in each group, (A) body weight and (B) body weight change were measured.

image.png

Fig.4 Detection of human LPA inhibition by Lepodisiran. Lepodisiran significantly reduced serum human LPA levels in a dose-dependent manner. 6-8-week-old, male pAlb-hLPA-Tg(V2) mice were assigned to four groups for saline or Leposiran (n=5 in each group). Following a single subcutaneous dose in each group, (A) serum hLPA levels and (B) hLPA inhibition were measured.


You may also like

Tamoxifen诱导Cre-ERT2小鼠 使用指南

Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。

Learn more

【小鼠大学问】基因工程小鼠的命名规则

常见的基因工程小鼠可以分为两种命名方式，包括基因定点修饰的小鼠命名，比如：敲除、敲入、点突变等等，和随机转基因的小鼠命名。

Learn more

Cre-lox系统介绍及使用汇总

你一定听说过Cre-lox重组系统，无论你是否直接进行过基因操作。由于Cre-lox系统具有操作简单、重组率高的优点，如今已经成为体内外遗传操作的强有力工具。利用Cre-lox系统，可以在特定细胞、组织或整个生物体，甚至在特定时间点敲除或表达某个基因，实现对特定基因的时空特异性操作，这对基因功能的研究和人类疾病动物模型的建立都具有深刻影响。

Learn more