hPCSK9

Fig.1 Expression of PCSK9 in the serum of humanized PCSK9 homozygous mice is detected by Elisa. (a) The expression of human PCSK9 can be detected in the serum collected from homozygous mice. (b) The expression of mouse PCSK9 can not be detected in the serum collected from homozygous mice.

Fig.2 Detection of the blood lipid index of (A) TG, (B) TC, (C) HDL-C and (D) LDL-C in chow diet-fed WT mice and HO hPCSK9 mice before treatment. (n=7-8, 6-week-old male mice).

Abbr. WT, wild type; HO, Homozygous; CD, chow diet.

Fig.3 Body weight in chow diet-fed and Evolocumab-treated HO hPCSK9 knockin mice (8 male mice in each group).

Abbr. HO, Homozygous; CD, chow diet.

Fig.4 Detection of the blood lipid index of (A) TG, (B) T-CHO, (C) HDL-C and (D) LDL-C in chow diet-fed and Evolocumab-treated HO hPCSK9 knockin mice. 

Blood lipids level of hPCSK9 mice before and after dosing were detected. Data were all normalized to control (8 male mice in each group. Mean ± SEM. *p < 0.05 and **p < 0.01 in Evolocumab group under t-test versus control).

Abbr. HO, Homozygous; CD, chow diet.

Fig.5 Liver weight-to-body weight ratio in chow diet-fed HO hPCSK9 knockin mice after 35 days of dosing (8 male mice in each group).

Abbr. HO, Homozygous; CD, chow diet.