hPCSK9

Nomenclature

C57BL/6Smoc-Pcsk9em2(hPCSK9)/Smoc

Cat. NO.

NM-HU-00075

Strain State

Repository Live

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Gene Summary

Gene Symbol
Pcsk9

Synonyms

AI415265; AI747682; FH3; HCHOLA3; Narc1; PC9

NCBI ID

100102

MGI ID

2140260

Ensembl ID

ENSMUSG00000044254

Pubmed

Pcsk9

Human Ortholog

PCSK9

Model Description

The endogenous mouse Pcsk9 gene was replaced by human PCSK9 gene .
Research Application：Immunotherapy,cancer research,drug screening

Validation Data

hPCSK9.png

Fig.1 Expression of PCSK9 in the serum of humanized PCSK9 homozygous mice is detected by Elisa. (a) The expression of human PCSK9 can be detected in the serum collected from homozygous mice. (b) The expression of mouse PCSK9 can not be detected in the serum collected from homozygous mice.

Publications

Targeting PCSK9 Ameliorates GraftVascular Disease in Mice by Inhibiting NLRP3 InflammasomeActivation in Vascular Smooth Muscle Cells
References：frontiers

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