SMOC has developed a set of mouse models expressing humanized immune checkpoints. These models are suitable to assess the efficacy of drugs targeting immune checkpoints in fully immunocompetent mice.
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Strain Name：C57BL/6Smoc-Tlr9em1(hTLR9)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18016
Research Application：drug screening
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Strain Name：C57BL/6Smoc-Tlr9em1(hTLR9)Tnfrsf4em3(hTNFRSF4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190024
Research Application：Immune-related
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Strain Name：C57BL/6Smoc-Tnfrsf1bem2(hTNFRSF1B)Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-220041
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Strain Name：C57BL/6Smoc-Tnfrsf12aem(hTNFRSF12A)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-230046
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Strain Name：C57BL/6Smoc-Trem2em4(hTRem2)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000083
Research Application：Alzheimer's disease research;drug screening
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Strain Name：C57BL/6Smoc-Vsirem1(hVSIR)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00118
Research Application：Immunotherapy,cancer research,drug screening
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Strain Name：C57BL/6Smoc-Vsig4em1(hVSIG4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210004
Research Application：inmmue therapy；drug screening
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Strain Name：C57BL/6Smoc-Ighmem1Ighdem1Sirpaem1(hSIRPA)Cd47em1(hCD47)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-232159
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Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-SIGLEC8-IRES-EGFP-WPRE-polyA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-210137
Research Application：Fluorescent reporter Mice
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Strain Name：C57BL/6Smoc-Cd40em1(hCD40)Rag2em1Il2rgem1/Smoc
Strain State：Developing | Cat. NO.：NM-HU-2000112
Research Application：Immunotherapy,cancer research,drug screening
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