SMOC has developed a set of mouse models expressing humanized immune checkpoints. These models are suitable to assess the efficacy of drugs targeting immune checkpoints in fully immunocompetent mice.
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Strain Name：C57BL/6JSmo-Timd4tm1(hTIMD4)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-215055
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Strain Name：C57BL/6JSmo-Tlr2tm2(hTLR2)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190066
Research Application：Immunotherapy,cancer research,drug screening
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Strain Name：C57BL/6JSmo-Tlr4tm2(hTLR4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000025
Research Application：Immunotherapy,drug screening
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Strain Name：C57BL/6JSmo-Tlr7tm1(hTLR7)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18027
Research Application：Immunotherapy,Cancer research,Drug screening
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Strain Name：C57BL/6JSmo-Tlr8tm2(TLR8)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190044
Research Application：Immunotherapy,cancer research,drug screening
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Strain Name：C57BL/6JSmo-Tlr8tm2(TLR8)Pdcd1tm1(hPDCD1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200276
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Strain Name：C57BL/6JSmo-Lyz2tm3(IRES-DTREGFP)Tlr8tm2(TLR8)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200259
Research Application：tumor research；inmmue therapy；drug screening;myeloid cell-specific DTR mice
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Strain Name：C57BL/6JSmo-Tlr9tm1(hTLR9)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18016
Research Application：drug screening
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Strain Name：C57BL/6JSmo-Tlr9tm1(hTLR9)Tnfrsf4tm3(hTNFRSF4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190024
Research Application：Immune-related
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Strain Name：C57BL/6JSmo-Tnfrsf1btm2(hTNFRSF1B)Pdcd1tm1(hPDCD1)Cd274tm1(hPD-L1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220041
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