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Models

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Mice

hCCR8/hPD-1

Strain Name：C57BL/6Smoc-Ccr8tm1(hCCR8)Pdcd1tm1(hPDCD1)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210400

hCCR8(NM-HU-190053) was crossed with hPD-1(NM-HU-00015) to generate hCCR8/hPD-1 mice.

Mice

Epcam-2A-CreERT2

Strain Name：C57BL/6Smoc-Epcamem1(2A-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00084
Validation Data：Presence

An 2A-CreERT2 co-expression cassette is inserted before 3'UTR region of Epcam gene .

Mice

hVEGFA(2)

Strain Name：C57BL/6Smoc-Vegfatm1(hVEGFA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-204984
Validation Data：Presence

The endogenous mice Vegfa gene was replaced by human VEGFA gene. While hVEGFA(Stock No.NM-HU-2000028) mice function similarly to hVEGFA(2) mice,for more detailed information please contact our technical advisor.

Mice

Braf-Flox-V600E

Strain Name：C57BL/6Smoc-Brafem1(flox-V600E)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190053

These mice carry a conditional p.V600E mutation of Braf gene.

Mice

hFCRN

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-hFcRn)Fcgrtem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00109
Validation Data：Presence

This FcRn humanized strain is established by mating endogenous mouse Fcgrt gene Knockout mice with R26-hFcRn(FCGRT) Knock-in mice. These FcRn humanized mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations. While hFCRN(2)(Stock No.NM-HU-190070) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN mice,for more detailed information please contact our technical advisor.

Mice

hCCR8/hCTLA-4

Strain Name：C57BL/6Smoc-Ccr8tm1(hCCR8)Ctla4tm1(hCTLA4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210435

hCCR8(NM-HU-190053) was crossed with hCTLA4(NM-HU-00014) to generate hCCR8/hCTLA4 mice.

Mice

A1cf-Flox

Strain Name：C57BL/6Smoc-A1cfem1(flox)Smoc
Strain State：Developing | Cat. NO.：NM-CKO-253742

These mice carry loxP sites flanking exon 4 of A1cf gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of A1cf gene.

Mice

hFCRN(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Fcgrttm2(FCGRT)Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-020
Validation Data：Presence

The background of this strain is NMG, and its endogenous Fcgrt gene is replaced with human FCGRT.

Mice

Axl-KO

Strain Name：C57BL/6Smoc-Axlem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-200044

Exon 3 of Axl gene was deleted to generate Axl knockout mice.

Mice

Pten-KO

Strain Name：C57BL/6Smoc-Ptenem3Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18002

Exon5 of Pten gene was deleted to generate Pten knockout mice.

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