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Models

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Mice

Pdcd1-DTR-2A-tdTomato

Strain Name：C57BL/6JSmo-Pdcd1em1(DTR-2A-tdTomato-WPRE-pA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200225

A DTR-2A-tdTomato-WPRE-pA expression cassette was knocked into the Pdcd1 gene start codon site.

Mice

hTREM2

Strain Name：C57BL/6JSmo-Trem2tm4(hTRem2)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000083
Validation Data：Presence

The endogenous mouse Trem2 gene was replaced by human TREM2 gene.

Mice

hCRBN

Strain Name：C57BL/6JSmo-Crbntm1(hCRBN)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225071
Validation Data：Presence

The endogenous mouse Crbn gene was replaced by human CRBN gene.

Mice

Itgax-2A-tdTomato-2A-DTR

Strain Name：C57BL/6JSmo-Itgaxem(T2A-tdTomato-P2A-DTR)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-204992
Validation Data：Presence

T2A-tdTomato-P2A-DTR expression cassette was knocked into the Itgax gene .

Mice

hAR

Strain Name：C57BL/6JSmo-Artm2(hAR)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225061
Validation Data：Presence

The endogenous mouse Ar gene was replaced by human AR gene.

Mice

hCD19/hCD3E

Strain Name：C57BL/6JSmo-Cd19tm1(hCD19)Cd3etm1(hCD3E)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190027
Validation Data：Presence

This CD19 and CD3E double knockin strain is established by crossing CD19-HU and CD3E-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

Cdh5-2A-CreERT2

Strain Name：C57BL/6JSmo-Cdh5em1(2A-CreERT2-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200173
Validation Data：Presence

A 2A-CreERT2-WPRE-polyA expression cassette was knocked into the Cdh5 gene stop codon site.

Mice

Agxt-KO

Strain Name：C57BL/6JSmo-Agxtem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-210152

Exon 3-8 of Agxt gene was deleted to generate Agxt knockout mice.

Mice

Axl-KO

Strain Name：C57BL/6JSmo-Axlem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-200044

Exon 3 of Axl gene was deleted to generate Axl knockout mice.

Mice

hSTING

Strain Name：C57BL/6JSmo-Tmem173tm2(hTMEM173)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190036
Validation Data：Presence

The endogenous mouse Tmem173 gene was replaced by human TMEM173 gene.

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