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Models

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Mice

hVISTA

Strain Name：C57BL/6Smoc-Vsirtm1(hVSIR)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00118
Validation Data：Presence

The exon 2-3 of endogenous mouse Vsir gene was replaced by the exon 2-3 of human VSIR(VISTA) gene.

Mice

hTNFR2

Strain Name：C57BL/6Smoc-Tnfrsf1btm2(hTNFRSF1B)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190010
Validation Data：Presence

The endogenous mouse Tnfrsf1b gene was replaced by human TNFRSF1B gene.

Mice

hTIGIT

Strain Name：C57BL/6Smoc-Tigittm1(hTIGIT)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00053
Validation Data：Presence

The endogenous mouse Tigit gene was replaced by human TIGIT gene. While hTIGIT(3)(Stock No.NM-HU-200244) mice function similarly to hTIGIT mice,for more detailed information please contact our technical advisor.

Mice

hCB1

Strain Name：C57BL/6Smoc-Cnr1tm1(hCB1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225027
Validation Data：Presence

The endogenous mouse Cnr1 gene was replaced by human CB1 gene.

Mice

Cav1-KO

Strain Name：C57BL/6Smoc-Cav1em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190930

Exon 3 of Cav1 gene was deleted to generate Cav1 knockout mice.

Mice

Wnt5b-IRES-CreERT2-2A-tdTomato

Strain Name：C57BL/6Smoc-Wnt5bem(IRES-CreERT2-P2A-tdTomato)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-215083

IRES-CreERT2-P2A-tdTomato expression cassette was knocked into the Wnt5b gene .

Mice

hTLR9

Strain Name：C57BL/6Smoc-Tlr9tm1(hTLR9)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18016
Validation Data：Presence

This TLR9 humanized mouse model was established by replacing the mouse Tlr9 gene exon2 with the human TLR9 corresponding sequence by homologous recombination.

Mice

H11-CAG-LSL-Myc

Strain Name：C57BL/6Smoc-Igs2em1(CAG-LSL-Myc)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00039
Validation Data：Presence  |  Publications：2piece

The c-Myc gene (also known as Myc) is abnormally expressed in many tumors and plays a critical role in the regulation of cell proliferation, growth and metabolism, gene instability, stimulation of angiogenesis, malignant transformation, cell differentiation and apoptosis. These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Myc oncogene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. Myc is expressed when bred to mice that express Cre recombinase.

Mice

H11-pAlb-hALB-IRES-Luc

Strain Name：C57BL/6Smoc-Igs2tm1(ALB promoter-human ALB-IRES-Luciferase-polyA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200322

An ALB promoter-human ALB-IRES-Luciferase-polyA expression cassette was knocked into the H11 locus.

Mice

Anxa10-2A-CreERT2

Strain Name：C57BL/6Smoc-Anxa10em1(2A-CreERT2-Wpre-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200312
Validation Data：Presence

2A-CreERT2-Wpre-pA expression cassette was knocked into the Anxa10 gene stop codon site.

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