Welcome to Advanced Search

CKO mice developed by SMOC supported the identification of a novel lncRNA that regulates dendritic cell migration and the corresponding immune response

CKO mice lncRNA dendritic cell

Advancing Cancer Therapy: Harnessing In Vivo Tumor Models for Breakthrough Drug Development

Cancer therapy advancements In vivo tumor models Preclinical cancer research Drug development in oncology Gene-modified cell lines Immuno-oncology Tumor modeling for drug discovery Cancer drug development Animal modeling services Cancer drug preclinical models

Join us for an insightful webinar exploring the critical role of in vivo tumor models in advancing cancer drug therapy. We will provide an overview of the diverse tumor models developed by our company, highlighting case studies demonstrating their effectiveness in preclinical cancer research. The session will delve into the comprehensive use of gene-modified cell lines and genetically modified spontaneous mouse models, showcasing their application in mimicking human cancer biology. We will conclude with a brief introduction to our company and our commitment to accelerating cancer drug development through innovative animal modeling services.

News Update: GenoBioTX and Crown Bioscience Sign Global Cooperation Agreement

Evaluating the Efficacy of Tumor-targeted Antibody in vivo

immunotherapy immune checkpoint immune checkpoint genes

As the most frequently used animal model, mice have been widely applied in the evaluation of drug efficacy. However, the human immune checkpoint genes only share ~60% identity with their murine counterparts. Thus antibodies that recognize human proteins do not necessarily interact with murine proteins, making it inappropriate to use wild type mice for evaluating the in vivo efficacy of human-specific antibody. The humanized immune checkpoint mouse models (Immune-Hu models), which were independently developed by Shanghai Model Organisms Center, are ideal models to evaluate the efficacy of anti-tumor antibody therapy.

Literature

Document literature

You can download our product and service brochures here for easy access.

Model Repository

model repository

Shanghai Model Organisms has established more than 18,000 genetically modified mouse models using three core technologies of gene editing. It has more than 10,000 proprietary genetically engineered mouse models that can be directly used for studies on gene functions, drug screening, and human diseases. At the same time, Shanghai Model Organisms has more than 30 fluorescent-labeled tumor cell lines, which can be used for in vitro experiments, studies on tumor bearing mice and other tumor researches.

We Will be Attending AACR 2023 in Orlando!

Why IL-2 Still Holds Promise in Therapeutics of Cancer and Autoimmunity

Who We are

In Vitro Efficacy Evaluation