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Mice

hCTLA-4/hCD28(BALB/c)

Strain Name：BALB/cAnSmoc-Ctla4tm1(hCTLA4)Cd28tm1(hCD28)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-200226
Validation Data：Presence

The endogenous mice Ctla4 and Cd28 gene was replaced by human CTLA4 and CD28 gene.

Mice

hOX40/hCTLA-4

Strain Name：C57BL/6Smoc-Tnfrsf4tm3(hTNFRSF4)Ctla4tm1(hCTLA4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00105

These mice are OX40 and CTLA4 double knockin mouse models which can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hICOS/hICOSL

Strain Name：C57BL/6Smoc-Icosltm1(hICOSLG) Icostm1(hICOS)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18018
Validation Data：Presence

This ICOS and ICOSL double knockin strain is established by crossing ICOS-HU and ICOSL-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hSIRPA(2)/hCD47

Strain Name：C57BL/6Smoc-Sirpatm2(hSIRPA)Cd47tm1(hCD47)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000111
Validation Data：Presence

This SIRPA and CD47 double Knock-in strain is established by crossing hSIRPA and hCD47 mice together. These double double Knock-in mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.While hSIRPA/hCD47 (Stock No.NM-HU-190019) have been pulled from shelves for some reasons.

Mice

hPD-1

Strain Name：C57BL/6Smoc-Pdcd1tm1(hPDCD1) /Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00015
Validation Data：Presence  |  Publications：1piece

The endogenous mouse Pdcd1 gene was replaced by human PDCD1(PD-1) gene .

Mice

hPD-L1

Strain Name：C57BL/6Smoc-Cd274tm1(hPD-L1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00062
Validation Data：Presence  |  Publications：1piece

The endogenous mouse Cd274(also known as PD-L1) gene was replaced by human PD-L1 gene . While hPD-L1(2)(Stock No.NM-HU-190039) mice function similarly to hPD-L1 mice,for more detailed information please contact our technical advisor.

Mice

h4-1BB(2)

Strain Name：C57BL/6Smoc-Tnfrsf9tm2(TNFRSF9)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190077
Validation Data：Presence

The endogenous mouse Tnfrsf9 gene was replaced by human TNFRSF9(4-1BB) gene. While h4-1BB mice(Stock No.NM-HU-00099）have been pulled from shelves for some reasons.

Mice

h4-1BBL

Strain Name：C57BL/6Smoc-Tnfsf9tm1(hTNFSF9)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00048
Validation Data：Presence

The endogenous mouse Tnfsf9 gene was replaced by human TNFSF9 gene.

Mice

Rag2/IL2rg-KO/hCD40

Strain Name：C57BL/6Smoc-Cd40tm1(hCD40)Rag2em1Il2rgem1Smoc
Strain State：Developing | Cat. NO.：NM-HU-2000112

The Rag2 and Il2rg genes of the CD40 humanized mouse were deleted.

Mice

hCCR2

Strain Name：C57BL/6Smoc-Ccr2tm2(hCCR2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18026
Validation Data：Presence

The endogenous mouse Ccr2 gene was replaced by human CCR2 gene.

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