In Vitro Efficacy Evaluation

In recent years, antibody drugs represented by immune checkpoint inhibitors have become a hot spot in the development of innovative drug. In this process, the in vitro efficacy evaluation model play an irreplaceable role, which can greatly accelerate the process of antibody drugs discovery, screening and optimization. We focused on the research and development of innovative antibody drugs, and it took 7 years to establish a stable, efficient and reliable in vitro efficacy evaluation platform.

According to the target mechanism, we systematically developed stable cell efficacy models of tumor surface antigens, suppressive immune checkpoints, co-stimulated immune checkpoints, and other immunomodulators to ensure the high-quality and efficient promotion of candidate antibody cell efficacy screening.

The platform has experience in in vitro efficacy evaluation of 200+ projects, and has established mature cell pharmacodynamic models of 60+ targets, tumor cell lines of 100+ targets, 10+ human primary cells, 40+ SOP guidance. It only takes 6 days to complete all in vitro efficacy evaluations of candidate molecules.

Service Highlights

1. Diverse tumor target selection

• It can evaluate any tumor treatment drug target and different drug mechanisms without fear of difficulty.

2. Well-established in vitro evaluation system

• in vitro evaluation system.

3. Extensive primary cell models

• A full range of human/mouse primary cells resource, presenting the in vivo mechanism of action to the greatest extent in vitro.

4. Customized development with high success rate

• The multi-dimensional pharmacodynamic evaluation system can be customized according to the target pharmacodynamic mechanism.

5. High standard quality system

• Evaluate the efficacy model from dimensions such as linearity, precision, accuracy, and stability to ensure higher quality.