Knockout mouse model is a laboratory mouse in which researchers have inactivated, or "knocked out," an existing gene by deleting portions of the gene’s DNA sequence, or by replacing the gene with an altered DNA sequence. Knockout mice exhibit modifications in phenotype (observable traits) and thereby provide important clues about the function of individual genes. Mice and humans share many genes in common. Hence, information from knockout mouse models can shed light on the biological roles of specific genes as well as on the involvement of those genes in human disease.
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Strain Name：C57BL/6JSmo-Grin2Aem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190968
Research Application：Nervous system, LTP action, dopamine and serotonin metabolism
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Strain Name：C57BL/6JSmo-Grin2aem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-210205
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Strain Name：C57BL/6JSmo-Grin2Cem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190587
Research Application：This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development.
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Strain Name：C57BL/6JSmo-Grin2cem2Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-210254
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Strain Name：C57BL/6JSmo-Grin2dem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-200846
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Strain Name：C57BL/6JSmo-Grin3aem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200847
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Strain Name：C57BL/6JSmo-Grin3bem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-200848
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Strain Name：C57BL/6JSmo-Grip1em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-201287
Disease Connection：Fraser syndrome, recessive dystrophic epidermolysis bullosa
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Strain Name：C57BL/6JSmo-Grip1em2Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-232951
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