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SCID

Strain Name：CB17-Prkdcscid/Smoc
Strain State：Repository Live | Cat. NO.：SM-015
Validation Data：Presence

SCID mice, or severe combined immunodeficiency mice, were first identified in 1983 by Bosma M.J. in the United States from the C.B.-17/Icr inbred strain. This condition arises from a mutation in a single recessive gene located on chromosome 16, also termed the SCID gene. SCID mice constitute an inbred homozygous line of C.B-17/IcrJ, exhibiting white coat colouration. This strain displays severe combined immunodeficiency, characterised by the absence of B-cell and T-lymphocyte function. Most homozygotes lack detectable levels of IgM, IgG1, IgG2a, IgG2b, IgG3, or IgA, and their thymus, lymph nodes, and splenic follicles contain almost no lymphocytes. However, the strain possesses normal NK cells, macrophages, and granulocytes. SCID mice are frequently used for inoculation with allogeneic or xenogeneic grafts, making them an ideal model for cell transplantation experiments.

BALB/c

Strain Name：BALB/cAnSmoc
Strain State：Repository Live | Cat. NO.：SM-003

BALB/c is one of the most widely used inbred lines in biomedical research, especially in immunology and infectious disease research. The incidence of breast tumors is about 10% to 20%. There is a certain number of ovarian, adrenal, pulmonary tumors, and leukemia that occurs. Lung cancer occurs in 26% of female mice and 29% of male mice. The incidence of leukemia is 12% in females and 10% in males. Blood pressure was the highest compared to other inbred mice and had spontaneous hypertension.

C57BL/6

Strain Name：C57BL/6
Strain State：Repository Live | Cat. NO.：SM-001
Validation Data：Presence

It was the first mouse strain to have its genome sequenced. With black coat color, it is recognized as the "standard" inbred strain and provides genetic background for numerous mutant genes. It is characterized by stable strain properties, ease of breeding, uniform stress responses, and high precision in experimental results.

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Model organisms are instrumental to the study of gene functions. Gene editing technology has always played a crucial role in the research on gene functions, diseases and drug discovery, through its application in genetic engineering of model organisms, mimicking of human diseases, as well as observation of physiological or pathological changes. In particular, the CRISPR/Cas9 technology has achieved remarkable breakthroughs in recent years, significantly improving the efficiency of genetic engineering in model organisms, and facilitating more extensive and in-depth applications of animal models in various research fields.