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SCID

Strain Name：SCID/NifdcSmoc
Strain State：Repository Live | Cat. NO.：SM-015

SCID mice, also known as Severe Combined Immune Deficient mice, were first discovered in 1983 by Bosma M.J. from the C.B-17/Icr inbred strain of mice. This condition is caused by a mutation in a single recessive gene located on chromosome 16, also referred to as the SCID gene. SCID mice are a congenic strain of C.B-17/lcrJ, with white fur. This strain exhibits severe combined immune deficiency, characterized by the absence of functional B cells and T lymphocytes. Most homozygotes lack detectable levels of IgM, IgG1, IgG2a, IgG2b, IgG3, or IgA. Additionally, the thymus, lymph nodes, and splenic follicles of these mice are virtually devoid of lymphocytes. However, SCID mice possess normal natural killer (NK) cells, macrophages, and granulocytes. SCID mice are commonly used for the transplantation of allogeneic or xenogeneic tissues and are ideal models for cell transplantation experiments.

BALB/c

Strain Name：BALB/cAnSmoc
Strain State：Repository Live | Cat. NO.：SM-003

BALB/c is one of the most widely used inbred lines in biomedical research, especially in immunology and infectious disease research. The incidence of breast tumors is about 10% to 20%. There is a certain number of ovarian, adrenal, pulmonary tumors, and leukemia that occurs. Lung cancer occurs in 26% of female mice and 29% of male mice. The incidence of leukemia is 12% in females and 10% in males. Blood pressure was the highest compared to other inbred mice and had spontaneous hypertension.

C57BL/6

Strain Name：C57BL/6Smoc
Strain State：Repository Live | Cat. NO.：SM-001

C57BL/6 mice have a high reproductive capacity, a long life span, and a low tumor susceptibility. Male mice are aggressive and fight frequently. Diet can cause obesity, type II diabetes, and atherosclerosis in these mice. The C57BL/6 mouse is the first to have its entire genome sequenced. It is the most extensively used inbred mouse strain as a genetic basis for congenic and mutant mice. It is also used in genetics, metabolism, immunology, neurology, behavioral research, pharmacodynamics, and medication safety evaluation.

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Model organisms are instrumental to the study of gene functions. Gene editing technology has always played a crucial role in the research on gene functions, diseases and drug discovery, through its application in genetic engineering of model organisms, mimicking of human diseases, as well as observation of physiological or pathological changes. In particular, the CRISPR/Cas9 technology has achieved remarkable breakthroughs in recent years, significantly improving the efficiency of genetic engineering in model organisms, and facilitating more extensive and in-depth applications of animal models in various research fields.