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Models

About 17 results
Mice

Abcb4-KO(FVB)

Strain Name：FVB-Abcb4em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200584

Exon 3-4 of Abcb4 gene was deleted to generate Abcb4 knockout mice.

Mice

Rag2-KO(FVB)

Strain Name：FVB-Rag2em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-233033

The exon3 of Rag2 gene was deleted to generate Rag2 knockout mouse.

Mice

Cyp3a-KO(FVB)

Strain Name：FVB-Cyp3a57em1Cyp3a59em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18056

All genes between Cyp3a57 and Cyp3a59 (including Cyp3a11, Cyp3a16, Cyp3a25, Cyp3a41, Cyp3a44, Cyp3a57, Cyp3a58-ps, Cyp3a59) were knocked out to generate Cyp3a-KO(FVB) mice (Stock No.NM-KO-18056). All genes between Cyp3a57 and Cyp3a59 (including Cyp3a11, Cyp3a16, Cyp3a25, Cyp3a41, Cyp3a44, Cyp3a57, Cyp3a58-ps, Cyp3a59) and Cyp3a13 were knocked out to generate Cyp3a-KO(FVB,2) mice (Stock No.NM-KO-190427).

Mice

Mir22-KO(FVB)

Strain Name：FVB-Mir22tmSmoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-210396

These mice carry a knock-out mutation of Mir22 (microRNA 22)

Mice

Cyp3a-KO(FVB,2)

Strain Name：FVB-Cyp3a57em2Cyp3a59em2Cyp3a13em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190427

All genes between Cyp3a57 and Cyp3a59 (including Cyp3a11, Cyp3a16, Cyp3a25, Cyp3a41, Cyp3a44, Cyp3a57, Cyp3a58-ps, Cyp3a59) and Cyp3a13 were knocked out to generate Cyp3a-KO(FVB,2) mice (Stock No.NM-KO-190427).All genes between Cyp3a57 and Cyp3a59 (including Cyp3a11, Cyp3a16, Cyp3a25, Cyp3a41, Cyp3a44, Cyp3a57, Cyp3a58-ps, Cyp3a59) were knocked out to generate Cyp3a-KO(FVB) mice (Stock No.NM-KO-18056).

Mice

Tor4a-KO(FVB)

Strain Name：FVB-Tor4aem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-240034

The exon 2 of Tor4a gene was deleted to generate Tor4a knockout mouse.

Mice

Vgll3-KO(FVB)

Strain Name：FVB-Vgll3em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-250606

The exon 2 of Vgll3 gene was deleted to generate Vgll3 knockout mouse.

Mice

Vgll1-KO(FVB)

Strain Name：FVB-Vgll1em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-250607

The exon 3 of Vgll1 gene was deleted to generate Vgll1 knockout mouse.

Mice

R26-pAPOE-hCYP3A4(FVB)

Strain Name：FVB-Gt(ROSA)26Sorem1(pAPOE-CYP3A4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18032

This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the liver-specific APOE promoter into the mouse Rosa26 site, which can be used to obtain liver-expressed CYP3A4 humanized model after mating with the Cyp3a13 gene and other Cyp3a family gene knockout mice. This model can be used with NM-KI-18033 mice which has gut-specific expression of human CYP3A4 to compare the contribution of intestinal versus hepatic metabolism to the biotransformation of a test article.

Mice

Abcb1a/Abcb1b-KO(FVB)

Strain Name：FVB-Abcb1aem1Abcb1bem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-191211

All sequences between exon2 of Abcb1a gene and exon28 of Abcb1b gene were knocked out by CRISPR/Cas9 technology.

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