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Literature

Raddeanin A, a triterpenoid saponin isolated from Anemone raddeana, suppresses the angiogenesis and growth of human...

Model Organisms：斑马鱼 Product & Service：- Research field：Drug screening and drug mechanism

raddeanin a 肿瘤血管生成 VEGFR 异种移植模型 结直肠肿瘤 海葵

Published date：2015-01-01 | References：Phytomedicine

Literature

Wnt pathway is involved in pleomorphic adenomas induced by overexpression of PLAG1 in transgenic mice

Model Organisms：小鼠 Product & Service：PLAG1 Research field：Cancer

涎腺肿瘤 β-catenin

Published date：2006-02-01 | References：Int J Cancer

Literature

FAF1 phosphorylation by AKT accumulates TGF-beta type II receptor and drives breast cancer metastasis

Model Organisms：小鼠 Product & Service：Faf1 Research field：Breast cancer

TGF-β 肿瘤转移 抑癌因子 促癌因子 EIIa-Cre 广泛表达Cre

Published date：2017-04-01 | References：Nat Commun

Literature

Deletion of HNF1alpha in hepatocytes results in fatty liver-related hepatocellular carcinoma in mice

Model Organisms：小鼠 Product & Service：hnf1α Research field：Liver

脂质代谢 肝癌 肿瘤

Published date：2017-07-01 | References：FEBS Lett

Pages

Drug Screening

drug screening high throughput screening for drug discovery

With a comprehensive model organisms service platform that generates the mouse, zebrafish and C. elegans models, Shanghai Model Organisms enables high-throughput drug screening as well as the evaluation and research on drug efficacy, thus accelerating drug development and achieving greater accuracy in the prediction of in vivo interactions.

Pages

Disease Mouse Models (Non-genetically-engineered)

diseases mice diseases model non genetically modified organisms

Shanghai Model Organisms has established a library of typical mouse models of human diseases through surgery or drug induction, thereby providing useful animal models for the research on pathogenesis of related diseases, functional studies of genes or proteins in diseases, screening of disease drugs and evaluation of therapeutic effects, etc.

Pages

Research on Diseases

genetics diseases studies diseases research diseases

Shanghai Model Organisms provides a professional R&D platform for genetically-engineered mouse, zebrafish and nematode models, a service platform for phenotyping, and a rich repository of disease mouse models to support your studies on disease genetics, pathogenesis, drug treatments, and more.

Pages

Cancer Model

research on cancer cancer model mouse models of cancer

The laboratory mouse is widely considered as a valid and affordable model organism for studying human disease. Mouse models of cancer not only enable researchers to understand the genetic basis of tumor development in complicated and dynamic physiological systems, but also serve as irreplaceable tools for developing and testing new therapies.  Shanghai Model Organisms Center offers a variety of mouse models of cancer to meet the needs of both academic and industry partners.

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