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Models

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Mice

Il17f-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il17fem1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00031

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon.The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il17f.

Mice

hIL2-Tg(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Tg(hIL2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-NSG-010
Validation Data：Presence

These transgenic mice carry humanized IL2.

Mice

Lepr-RSR-CreERT2

Strain Name：C57BL/6Smoc-Leprtm1(rox-stop-rox-CreERT2-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-210112

rox-stop-rox-CreERT2-WPRE-polyA expression cassette was knocked into the Lepr gene.

Mice

R26-CAG-LSL-hEML4/ALK*F1174L-Luc-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(SA-2xpolyA-CAG-LSL-EML4-ALK(F1174L)-IRES-luciferase-2A-tdTomato)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-190010

A SA-2xpolyA-CAG-LSL-EML4-ALK(F1174L)-IRES-Luciferase-2A-tdTomato-WPRE-polyA cassette was inserted at the Rosa26 locus. When bred to a strain expressing Cre recombinase under control of various tissue specific promoters, Cre recombination deletes the LSL cassette and allows the expression of the EML4-ALK(F1174L) protein.

Mice

hIL2

Strain Name：C57BL/6Smoc-Il2tm3(hIL2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190048
Validation Data：Presence

The endogenous mouse Il2 gene was replaced by human IL2 gene.

Mice

Il17c-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il17cem1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00030

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il17c.

Mice

Sox2-CreERT2

Strain Name：C57BL/6Smoc-Sox2em1(CreERT2-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200084
Validation Data：Presence

The coding region of Sox2 gene was replaced by a CreERT2-polyA expression cassette.

Mice

R26-CAG-LSL-hIDH2*R140Q-IRES-Luc-2A-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-LSL-IDH2(R140Q)-IRES-Luciferase-2A-tdTomato)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-190075

These mice harbor a CAG-LSL-IDH2(R140Q)-IRES-Luciferase-2A-tdTomato cassette in the Rosa26 locus generated by homologous recombination.

Mice

Rag1-KO

Strain Name：C57BL/6Smoc-Rag1em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-252600

The exon 2 of Rag1 gene was deleted to generate Rag1 knockout mouse.

Mice

hPD-1/hPD-L1/hCD47/hSIRPA(BALB/c)

Strain Name：BALB/cAnSmoc-Pdcd1tm(hPDCD1)Cd274tm(hPD-L1)Sirpatm4(hSIRPA)Cd47tm1(hCD47)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220143

hSIRPA/hCD47(BALB/c)(NM-HU-210020) mice was crossed with hPD-1/ hPD-L1(BALB/c)(NM-HU-220142) mice to generate hPD-1/hPD-L1/hCD47/hSIRPA(BALB/c) mice.

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