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Models

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Mice

Pvalb-2A-mCherry

Strain Name：C57BL/6Smoc-Pvalbem(2A-mCherry)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-220177

2A-mCherry expression cassette was knocked into the Pvalb gene stop codon site.

Mice

hPD-1/hPD-L1/hLAG3

Strain Name：C57BL/6Smoc-Pdcd1tm1(hPDCD1)Cd274tm1(hPD-L1)Lag3tm1(hLAG3)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190028

hPD-1(NM-HU-00015),hPD-L1(NM-HU-00062) were crossed with hLAG3(NM-HU-00049) to generate hPD-1/hPD-L1/hLAG3.

Mice

Bag3-Flox

Strain Name：C57BL/6Smoc-Bag3em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-2101856

These mice carry loxP sites flanking exon 4 of Bag3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Bag3 gene.

Mice

Col1a1-IRES-CreERT2

Strain Name：C57BL/6Smoc-Col1a1em(IRES-CreERT2)1Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-225031
Validation Data：Presence

IRES-CreERT2 expression cassette was knocked into the Col1a1 gene. The strain cannot breed homozygotes, and it is recommended to use heterozygotes for research.

Mice

Notch1-CreERT2

Strain Name：C57BL/6Smoc-Notch1em1(CreERT2-2xpA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200122
Validation Data：Presence

A CreERT2-2xpA expression cassette was knocked into the Notch1 gene start codon site. Notch1 performs vital cell functions, such as proliferation, differentiation, apoptosis, and stem cell maintenance. When Notch1-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in NOTCH1 positive cells.

Mice

hNR3C1

Strain Name：C57BL/6Smoc-Nr3c1tm1(hNR3C1)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-225058

The endogenous mouse Nr3c1 gene was replaced by human NR3C1 gene.

Mice

hIL5/hIL5R(2)

Strain Name：C57BL/6Smoc-Il5tm3(hIL5)Il5ratm2(hIL5RA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-220010
Validation Data：Presence

The endogenous mouse Il5 and Il5ra genes was replaced by human IL5 and IL5ra genes. While hIL5/hIL5R(Stock No.NM-HU-2000101) mice and hIL5/hIL5R(3)(Stock No.NM-HU-220011) function similarly to hIL5/hIL5R(2) mice, for more detailed information please contact our technical advisor.

Mice

Lepr-KO

Strain Name：C57BL/6Smoc-Leprem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190663

Exon 5 of Lepr gene was deleted to generate Lepr knockout mice.

Mice

Il10-KO(BALB/c)

Strain Name：BALB/cAnSmoc-Il10em4Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-200637

Exon 1-5 of Il10 gene was deleted to generate Il10 knockout mice.

Mice

hGEM

Strain Name：C57BL/6Smoc-Gemtm1(hGem)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200249

The endogenous mice Gem gene was replaced by human GEM gene.

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