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Models

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Mice

Meox1-Dre

Strain Name：C57BL/6Smoc-Meox1em1(Dre-Wpre-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200174

A Dre-Wpre-polyA expression cassette was knocked into the Meox1 gene start codon site.

Mice

hIGHA1

Strain Name：C57BL/6Smoc-sμtm1(hIGHA1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000086
Validation Data：Presence

The endogenous mouse sμ region was replaced by human IGHA1.

Mice

R26-CreERT2

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-FRT-2xpolyA-CAG-FRT-CreERT2-Rox-WPRE-Rox-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200041
Validation Data：Presence

These mice harbor a SA-FRT-2xpolyA-CAG-FRT-CreERT2-Rox-WPRE-Rox-polyA cassette in the Rosa26 locus generated by homologous recombination. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in multiple tissues after tamoxifen treatment.

Mice

hPD-1/hCD28

Strain Name：C57BL/6Smoc-Pdcd1tm1(hPDCD1)Cd28tm2(hCD28)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000097

hPD-1(NM-HU-00015) was crossed with hCD28(NM-HU-190011) to generate hPD-1/hCD28.

Mice

Il7r-Cre

Strain Name：C57BL/6Smoc-Il7rem1(Cre-Wpre-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200306
Validation Data：Presence

Cre-Wpre-pA expression cassette was knocked into the Il7r gene start codon site.

Mice

hLAG3/hCTLA-4

Strain Name：B6.129S-Lag3tm1(hLAG3)Ctla4tm1(hCTLA4)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190018

This LAG3 and CTLA4 double knockin strain is established by crossing LAG3-HU and CTLA4-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

Il17b-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il17bem1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00029

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il17b.

Mice

Il4-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il4em1(Luc-eGFP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00021
Validation Data：Presence

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon.The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il4.

Mice

Il15-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il15em1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00027

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il15.

Mice

Slc6a4-KO

Strain Name：C57BL/6Smoc-Slc6a4em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-200892

Exon 3-4 of Slc6a4 gene was deleted to generate Slc6a4 knockout mice.

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