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Models

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Mice

Notch1-CreERT2

Strain Name：C57BL/6JSmo-Notch1em1(CreERT2-2xpA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200122
Validation Data：Presence

A CreERT2-2xpA expression cassette was knocked into the Notch1 gene start codon site. Notch1 performs vital cell functions, such as proliferation, differentiation, apoptosis, and stem cell maintenance. When Notch1-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in NOTCH1 positive cells.

Mice

hGEM

Strain Name：C57BL/6JSmo-Gemtm1(hGem)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200249

The endogenous mice Gem gene was replaced by human GEM gene.

Mice

hIL5/hIL5R(2)

Strain Name：C57BL/6JSmo-Il5tm3(hIL5)Il5ratm2(hIL5RA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-220010
Validation Data：Presence

The endogenous mouse Il5 and Il5ra genes was replaced by human IL5 and IL5ra genes. While hIL5/hIL5R(Stock No.NM-HU-2000101) mice and hIL5/hIL5R(3)(Stock No.NM-HU-220011) function similarly to hIL5/hIL5R(2) mice, for more detailed information please contact our technical advisor.

Mice

hPD-1/hPD-L1/hCD47/hSIRPA(BALB/c)

Strain Name：BALB/cJSmo-Pdcd1tm(hPDCD1)Cd274tm(hPD-L1)Sirpatm4(hSIRPA)Cd47tm1(hCD47)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220143

hSIRPA/hCD47(BALB/c)(NM-HU-210020) mice was crossed with hPD-1/ hPD-L1(BALB/c)(NM-HU-220142) mice to generate hPD-1/hPD-L1/hCD47/hSIRPA(BALB/c) mice.

Mice

R26-CAG-LSL-hTARDBP*A315T-EGFP

Strain Name：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-3xFlag-TARDBP(A315T)-IRES-GFP-WPRE-PA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200019

These mice harbor a CAG-LSL-3xFlag-TARDBP(A315T)-IRES-GFP-WPRE-PA cassette in the Rosa26 locus generated by homologous recombination.

Mice

R26-CAG-2xKRAB-dCas9-IRES-EGFP

Strain Name：C57BL/6JSmo-Gt(ROSA)26Sorem1(CAG-Loxp-2xKRAB-dCas9-IRES-EGFP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-18007
Validation Data：Presence

These mice harbor a CAG-LSL-2xKRAB-dCas9-IRES-EGFP-WPRE-pA conditional expression cassette in mouse Rosa26 loci via homologous recombination. This strain can be used in CRISPR mediated target gene transcriptional inhibition (CRISPRi). The loxp-stop-loxp cassette was deleted.

Mice

ICR

Strain Name：ICR
Strain State：Repository Live | Cat. NO.：SM-006
Validation Data：Presence

ICR

Mice

hCD3EDG(BALB/c)

Strain Name：BALB/c-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)/CbSmoc
Strain State：Repository Live | Cat. NO.：NM-HU-220122
Validation Data：Presence

The endogenous mouse Cd3e/Cd3d/Cd3g genes were replaced by human CD3E/CD3D/CD3G gene.

Mice

Tmem119-IRES-Cre

Strain Name：C57BL/6JSmo-Tmem119em1(IRES-Cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-225007
Validation Data：Presence

IRES-Cre expression cassette was knocked into the Tmem119 gene stop codon site.

Mice

1300017j02Rik-KO

Strain Name：C57BL/6JSmo-1300017j02Rikem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190231

This 1300017j02Rik knockout mouse model was generated by knocking out the exon2-12 region of the 1300017j02Rik.

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