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Models

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Mice

Col1a1-TRE3G-dCas9-VPR-EGFP

Strain Name：C57BL/6JSmo-Col1a1em1(TRE3G-dCas9-VPR-eGFP-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-00123

These mice harbor a TRE3G-dCas9-VPR(VP64-p65-Rta)-eGFP-pA tetracycline-controlled transcriptional activation cassette in mouse Col1a1 loci. This strain can be used in CRISPR mediated target gene transcriptional activation (CRISPRa).

Mice

hPD-1/hOX40

Strain Name：C57BL/6JSmo-Pdcd1tm1(hPDCD1)Tnfrsf4tm3(hTNFRSF4) Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00108

hPD-1（NM-HU-00015）was crossed with hOX40（NM-HU-00041）to generate hPD-1/hOX40.

Mice

R26-CAG-LSL-hEGFR*L858R/T790M-IRES-Luc-2A-tdTomato

Strain Name：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-EGFR (L858R-T790M)-IRES-luciferase-2A-tdTomato)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190068

These mice harbor a CAG-LSL-EGFR (L858R-T790M)-IRES-luciferase-2A-tdTomato cassette in the Rosa26 locus generated by homologous recombination.

Mice

hCD74

Strain Name：C57BL/6JSmo-Cd74tm1(hCD74)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000082

The endogenous mouse Cd74 gene was replaced by human CD74 gene.

Mice

Zap70-W163C(Balb/c)

Strain Name：BALB/cJSmo-Zap70em(W163C)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-210366
Validation Data：Presence  |  Publications：1piece

These mice carry a W163C mutation of Zap70 gene.

Mice

hIGHG1

Strain Name：C57BL/6JSmo-Ighg1tm1(hIGHG1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225091
Validation Data：Presence

The endogenous mouse Ighg1 gene was replaced by human IGHG1 gene.

Mice

hSLAMF7

Strain Name：C57BL/6JSmo-Slamf7tm(hSLAMF7)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18028

The endogenous mouse Slamf7 gene was replaced by human SLAMF7 gene .

Mice

Il12a-Luc-2A-EGFP

Strain Name：C57BL/6JSmo-Il12aem1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00024

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il12a.

Mice

hCD96

Strain Name：C57BL/6JSmo-Cd96tm2(hCD96)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000059
Validation Data：Presence

The endogenous mouse Cd96 gene was replaced by human CD96 gene.

Mice

hGCGR

Strain Name：C57BL/6JSmo-Gcgrtm(hGCGR)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-215004
Validation Data：Presence

The endogenous mice Gcgr gene was replaced by human GCGR gene.

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