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Mice

hIL11/hIL11RA

Strain Name：C57BL/6JSmo-Il11tm1(hIL11)Il11ra1tm1(hIL11RA)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210372
Validation Data：Presence

hIL11(NM-HU-204981) was crossed with hIL11RA (NM-HU-204982) to generate hIL11/hIL11RA mice.

Mice

Il1a-Luc-2A-EGFP

Strain Name：C57BL/6JSmo-Il1aem1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00009
Validation Data：Presence

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon.

Mice

hPD-L1/hVEGFR2

Strain Name：C57BL/6JSmo-Cd274tm1(hCD274)Kdrtm2(hKDR)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000102

hPD-L1(NM-HU-00062) was crossed with hKDR(NM-HU-00098) to generate hPD-L1/hKDR.

Mice

Bmi1-IRES-CreERT2

Strain Name：C57BL/6JSmo-Bmi1em1(IRES-CreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200095
Validation Data：Presence

A IRES-CreERT2 expression cassette was knocked into the Bmi1 gene stop codon site.

Mice

hLAG3

Strain Name：B6.129S-Lag3tm1(hLAG3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00049
Validation Data：Presence

The endogenous mouse Lag3 gene exon1-7 was replaced by human LAG3 gene extracellular region by homologous recombination.

Mice

hIL1B

Strain Name：C57BL/6JSmo-Il1btm3(hIL1B)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190047
Validation Data：Presence

The endogenous mouse Il1b gene was replaced by human IL1B gene.

Mice

hPD-1/hPD-L1/hPD-L2

Strain Name：C57BL/6JSmo-Pdcd1lg2tm1(hPDCD1LG2)Pdcd1tm1(hPDCD1)Cd274tm1(hPD-L1)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190060

The endogenous mouse Pd-1/Pd-l1/Pdcd1lg2 gene was replaced by human PD-1/PD-L1/PDCD1LG2 gene.

Mice

Scgb1a1-IRES-CreERT2

Strain Name：C57BL/6JSmo-Scgb1a1em1(IRES-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200129
Validation Data：Presence

A IRES-CreERT2 expression cassette was knocked into the Scgb1a1 gene stop codon site.

Mice

Hopx-IRES-CreERT2

Strain Name：C57BL/6JSmo-Hopxem1(IRES-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200136
Validation Data：Presence

A IRES-CreERT2 expression cassette was knocked into the Hopx gene stop codon site.

Mice

Il17a-Cre

Strain Name：C57BL/6JSmo-Il17aem1(iCre-polyA(SV40))Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200137
Validation Data：Presence

A iCre-polyA expression cassette was knocked into the Il17a gene start codon site. This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying autoimmune inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis.

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