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Models

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Mice

hFCRN

Strain Name：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-hFcRn)Fcgrtem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00109
Validation Data：Presence  |  Publications：1piece

This FcRn humanized strain is established by mating endogenous mouse Fcgrt gene Knockout mice with R26-hFcRn(FCGRT) Knock-in mice. These FcRn humanized mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations. While hFCRN(2)(Stock No.NM-HU-190070) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN mice,for more detailed information please contact our technical advisor.

Mice

hCCR8(2)/hCTLA-4

Strain Name：C57BL/6JSmo-Ccr8tm3(hCCR8)Ctla4tm1(hCTLA4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220074
Validation Data：Presence

hCTLA4 (NM-HU-00014) mice were crossed with hCCR8(2) (NM-HU-2000054) mice to generate hCCR8(2)/hCTLA4 mice．

Mice

hCSF1R(2)

Strain Name：C57BL/6JSmo-Csf1rtm3(hCSF1R)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190074
Validation Data：Presence

The endogenous mouse Csf1r gene was replaced by human CSF1R gene. While hCSF1R (Stock No.NM-HU-00094) have been pulled from shelves for some reasons.

Mice

hCD40(BALB/c)

Strain Name：BALB/cJSmo-Cd40tm1(hCD40)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000047
Validation Data：Presence

The endogenous mouse Cd40 gene was replaced by human CD40 gene.

Mice

hSIRPA(2)

Strain Name：C57BL/6JSmo-Sirpatm2(hSIRPA)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-18015
Validation Data：Presence

The endogenous mouse Sirpa gene was replaced by human SIRPA gene . While hSIRPA (Stock No.NM-HU-00119) have been pulled from shelves for some reasons.

Mice

hTTR

Strain Name：C57BL/6JSmo-Ttrtm1(hTTR)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225087
Validation Data：Presence

The endogenous mouse Ttr gene was replaced by human TTR gene.

Mice

Cd68-2A-Cre

Strain Name：C57BL/6JSmo-Cd68em5(2A-Cre-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200192
Validation Data：Presence

This Cd68-Cre tool mouse model was established by inserting a 2A-Cre-WPRE-polyA co-expression cassette into the stop codon of Cd68 gene .

Mice

hCD24/hSIGLEC10

Strain Name：C57BL/6JSmo-Cd24atm1(hCD24)Siglecgtm1(hSIGLEC10)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210367
Validation Data：Presence

hCD24(NM-HU-2000060) was crossed with hSIGLEC10(NM-HU-2000061）to generate hCD24/hSIGLEC10 mice.

Mice

hTNFRSF1A

Strain Name：C57BL/6JSmo-Tnfrsf1atm(hTNFRSF1A)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-215017

The endogenous mice Tnfrsf1a gene was replaced by human TNFRSF1A gene.

Mice

hSEMA4D

Strain Name：C57BL/6JSmo-Sema4dtm1(hSEMA4D)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00117
Validation Data：Presence

The endogenous mouse Sema4d gene was replaced by human SEMA4D gene.

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