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Models

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Mice

hCCR8(2)/hCTLA-4

Strain Name：C57BL/6Smoc-Ccr8em3(hCCR8)Ctla4em1(hCTLA4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220074

hCTLA4 (NM-HU-00014) mice were crossed with hCCR8(2) (NM-HU-2000054) mice to generate hCCR8(2)/hCTLA4 mice．

Mice

hCFD

Strain Name：C57BL/6Smoc-Cfdem1(hCFD)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-225045

The endogenous mouse Cfd gene was replaced by human CFD gene.

Mice

hCD20(2)

Strain Name：C57BL/6Smoc-Ms4a1em3(hCD20)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200114

Extracellular and transmembrane region of the endogenous mouse Ms4a1 gene was replaced by corresponding region of human CD20 gene. While hCD20(Stock No.NM-HU-190068) mice function similarly to hCD20(2) mice,for more detailed information please contact our technical advisor.

Mice

hFCRN

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-hFcRn)Fcgrtem1/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00109

This FcRn humanized strain is established by mating endogenous mouse Fcgrt gene Knockout mice with R26-hFcRn(FCGRT) Knock-in mice. These FcRn humanized mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations. While hFCRN(2)(Stock No.NM-HU-190070) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN mice,for more detailed information please contact our technical advisor.

Mice

hTLR7

Strain Name：C57BL/6Smoc-Tlr7em1(hTLR7)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18027

The endogenous mouse Tlr7 gene was replaced by humanTLR7 gene.

Mice

hIL6R

Strain Name：C57BL/6Smoc-Il6raem1(hIL6R)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00044

The endogenous mouse Il6ra gene was replaced by human IL-6R gene .

Mice

hIL17A

Strain Name：C57BL/6Smoc-Il17aem1(hIL17A)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00042

The endogenous mouse Il17a gene was replaced by human IL17A gene.

Mice

Ctsk-2A-Cre

Strain Name：C57BL/6Smoc-Ctskem1(2A-Cre-Wpre-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190019

The 2A-Cre-Wpre-polyA cassette is inserted before 3'UTR region of Ctsk gene.

Mice

hCD180

Strain Name：C57BL/6Smoc-Cd180em1(hCD180)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210006

The endogenous mice Cd180 gene was replaced by human CD180 gene

Mice

hEGFR

Strain Name：C57BL/6Smoc-Egfrem1(hEGFR)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-200227

The endogenous mice Egfr gene was replaced by human EGFR gene. While hEGFR(2)(Stock No.NM-HU-200232) mice have been pulled from shelves for some reasons.

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