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Models

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Mice

Bmal1-Flox

Strain Name：C57BL/6JSmo-Bmal1em1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-200063

These mice carry loxP sites flanking exon 8 of Bmal1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Bmal1 gene.

Mice

Lrat-2A-Cre

Strain Name：C57BL/6JSmo-Lratem1(2A-Cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190097
Validation Data：Presence  |  Publications：1piece

A 2A-Cre expression cassette was knocked into the Lrat gene stop codon site.

Mice

hPD-L2

Strain Name：C57BL/6JSmo-Pdcd1lg2tm1(hPDCD1LG2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190050
Validation Data：Presence

将小鼠Pdcd1lg2基因全部或者部分替换为人源PDCD1LG2，从而表达人或人鼠嵌合PDCD1LG2蛋白，取代小鼠内源Pdcd1lg2蛋白的表达 hPD-L2.

Mice

Abcd1-KO

Strain Name：C57BL/6JSmo-Abcd1em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-2106014

Exon 2 of Abcd1 gene was deleted to generate Abcd1 knockout mice.

Mice

hCFD

Strain Name：C57BL/6JSmo-Cfdtm1(hCFD)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225045
Validation Data：Presence

The endogenous mouse Cfd gene was replaced by human CFD gene.

Mice

Tagln-Cre

Strain Name：C57BL/6JSmo-Taglnem1(Cre-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200144
Validation Data：Presence

A Cre-WPRE-polyA expression cassette was knocked into the Tagln gene start codon site. This gene encodes a smooth muscle cell-specific cytoskeletal protein. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in vascular smooth muscle cells. In mouse models of atherosclerosis, the gene product may be involved in plaque cell and atherosclerotic lesion formation during atherogenesis.

Mice

Rag2-KO(Rag2-EGFP)

Strain Name：B6;129S-Rag2tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00070
Validation Data：Presence

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag2 gene start codon site. As a Rag2 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag2 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Rorc-2A-tdTomato-2A-DTR

Strain Name：C57BL/6JSmo-Rorcem(T2A-tdTomato-P2A-DTR)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-204991

T2A-tdTomato-P2A-DTR expression cassette was knocked into the Rorc gene .

Mice

Abcg8-KO

Strain Name：C57BL/6JSmo-Abcg8em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200906

Exon 3 of Abcg8 gene was deleted to generate Abcg8 knockout mice.

Mice

hCD3E(2)

Strain Name：C57BL/6JSmo-Cd3etm2(hCD3E)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210023

The endogenous mice Cd3e gene was replaced by human CD3E gene. While hCD3E(Stock No.NM-HU-00114) mice function similarly to hCD3E(2) mice,for more detailed information please contact our technical advisor.

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