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Models

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Cells

MC38-hVEGFA(189)

Strain Name:MC38-hVEGFA(189)
Strain State : Validation of tumorigenic capacity completed |  Cat. NO.:NMC-250230

MC38 cell line with humanized VEGFA(189) gene

Cells

MC38-hVEGFA/hPD-L1

Strain Name:MC38-hVEGFA/hPD-L1
Strain State : Construction |  Cat. NO.:NMC-230122

VEGFA/CD247 gene humanized mouse cell line of MC38

Literature

HIF-1alpha and HIF-2alpha induced angiogenesis in gastrointestinal vascular malformation and reversed by thalidomide

Model Organisms:斑马鱼 Product & Service:HIF-2alpha Research field:Drug screening and drug mechanism

血管生成 Thalidomide 血管内皮生长因子 VEGF

Literature

Endothelial CDS2 Deficiency Causes VEGFA-mediated Vascular Regression and Tumor Inhibition

Model Organisms:Mouse Product & Service:cds2 Research field:Vascular Regression

Literature
Pages

Mouse models for cancer research

Tumor bearing Mouse DEN model PDX model CDX model

Shanghai Model Organisms Center provides multiple types of tumor-bearing mouse models for cancer research and drug efficacy testing, including cell line-derived xenograft model (CDX) and patient-derived xenograft model (PDX). While PDX models better reflect the heterogeneity and diversity of human cancers, CDX models allow researchers to advance their pre-clinical drug development in a cost- and time-efficient manner.

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