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Mice

Cck-IRES-Cre

Strain Name：C57BL/6Smoc-Cckem1(IRES-iCre-PolyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200131
Validation Data：Presence

A IRES-iCre-PolyA expression cassette was knocked into the Cck gene stop codon site.

Mice

H11-CAG-RSR-EYFP

Strain Name：C57BL/6Smoc-Igs2em1(CAG-RSR-EYFP)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-18056

A CAG-ROX-STOP-ROX-EYFP-V5tag-polyA conditional expression cassette was knocked into the Igs2 locus (Hipp11 or H11; an intergenic region on chromosome 11 [cytoband A1 at ~3cM between the Eif4enif1 and Drg1 loci] reported to support high-level global gene expression in conjunction with the CAG (CAGGS) promoter and a higher rate of mitotic/interchromosomal recombination compared to Gt(ROSA)26Sor) . This strain of mice can be used to mate with mice expressing the Dre recombinase. After exposure to Dre recombinase, expression of ellow fluorescent protein and V5 tag is observed for cell tracking.

Mice

Abcc8-KO(2)

Strain Name：C57BL/6Smoc-Abcc8em2Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-225150

exon 8-16 of Abcc8 gene was deleted to generate Abcc8 knockout mice.

Mice

Itgax-2A-tdTomato-2A-DTR

Strain Name：C57BL/6Smoc-Itgaxem(T2A-tdTomato-P2A-DTR)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-204992
Validation Data：Presence

T2A-tdTomato-P2A-DTR expression cassette was knocked into the Itgax gene .

Mice

hPVR

Strain Name：C57BL/6Smoc-Pvrtm1(hPVR)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190012
Validation Data：Presence

The endogenous mouse Pvr gene was replaced by human PVR gene.

Mice

Gad2-IRES-Cre

Strain Name：C57BL/6Smoc-Gad2em1(IRES-iCre-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200078
Validation Data：Presence

A IRES-iCre-pA expression cassette was knocked into the Gad2 gene stop codon site.

Mice

CAG-LSL-dCas9-SPH-Tg

Strain Name：C57BL/6Smoc-Tg(CAG-LSL-dCas9-SPH)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-00025
Publications：1piece

Cre-dependent SunTag-p65-HSF1 (SPH) transgenic mice were generated with piggyBac transposon system in F1 zygotes and crossed with wild type C57BL/6 mice., SPH transgenic mouse containing HA-tagged dCas9 fused with 10xGCN4, which is linked with p65-HSF1 and EGFP in tandem via P2A and T2A respectively. The transgene is driven by the ubiquitous CAG promoter and interrupted by a loxP-stop-loxP (LSL) cassette to render Cas9 expression inducible by the Cre recombinase. Expression of dCas9 can be detected using primary antibody: rabbit monoclonal antibody to HA-tag (1:1000, #3724, CST45) and secondary antibody: goat anti-rabbit Alexa Fluor 488 (1:1000, #A-11034, Thermo Fisher). *This strain is a client-donated line. The donor's publication indicates that fluorescence was observed by immunofluorescence. The JAX description of this strain also explicitly states that fluorescence cannot be directly observed.

Mice

Avil-Cre

Strain Name：C57BL/6Smoc-Avilem1(Cre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-215036
Validation Data：Presence

Cre expression cassette was knocked into the Avil gene.

Mice

hIL6/hIL6R

Strain Name：C57BL/6Smoc-Il6tm1(hIL6)Il6ratm1(hIL6R)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190025
Validation Data：Presence

This IL6 and IL6R double knockin strain is established by crossing IL6-HU and IL6R-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

Il12b-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il12bem1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00025

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon.

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