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Does a mouse expressing the Cre gene only have a poor phenotype?

Cre activity translocation translocation meaning

Model Repository

model repository

Shanghai Model Organisms has established more than 18,000 genetically modified mouse models using three core technologies of gene editing. It has more than 10,000 proprietary genetically engineered mouse models that can be directly used for studies on gene functions, drug screening, and human diseases. At the same time, Shanghai Model Organisms has more than 30 fluorescent-labeled tumor cell lines, which can be used for in vitro experiments, studies on tumor bearing mice and other tumor researches.

Popular Model Organisms

genetically modified organisms transgenic organisms genetically modified organisms examples

Model organisms are instrumental to the study of gene functions. Gene editing technology has always played a crucial role in the research on gene functions, diseases and drug discovery, through its application in genetic engineering of model organisms, mimicking of human diseases, as well as observation of physiological or pathological changes. In particular, the CRISPR/Cas9 technology has achieved remarkable breakthroughs in recent years, significantly improving the efficiency of genetic engineering in model organisms, and facilitating more extensive and in-depth applications of animal models in various research fields.

Gene-editing proposal

model mouse

Using SMOC’s gene targeting artificial intelligent expert system-Smarteddi, you can input the name of the gene you want to knockout and the cloud-based search engine will show you the solution.

Mouse models for cancer research

Tumor bearing Mouse DEN model PDX model CDX model

Shanghai Model Organisms Center provides multiple types of tumor-bearing mouse models for cancer research and drug efficacy testing, including cell line-derived xenograft model (CDX) and patient-derived xenograft model (PDX). While PDX models better reflect the heterogeneity and diversity of human cancers, CDX models allow researchers to advance their pre-clinical drug development in a cost- and time-efficient manner.

Hemophilia Model

f8 gene f9 gene hemophilia research

The F8 and F9 gene knockout mice were generated by Shanghai Model Organisms Center (SMOC)

Dysgenesis model

infertility diseases prss37 gene KO mice

Prss37 gene knockout infertility mouse model. SMOC has developed the Prss37 gene knockout mouse model (Prss37 KO, Model No.: NM -KO-00016) by ES cell targeting. It is a homozygous male infertility model.

Inflammation Models

inflammation diseases inflammation research inflammatory factors

Inflammation is a common yet important pathological process. Any factor that may cause tissue damage can lead to inflammation. Anomal inflammatory response may result in chronic inflammation, autoimmune diseases and even cancer. The regulation of inflammation-related genes is an important topic in the study of the development of inflammation.

Cancer Model

research on cancer cancer model mouse models of cancer

The laboratory mouse is widely considered as a valid and affordable model organism for studying human disease. Mouse models of cancer not only enable researchers to understand the genetic basis of tumor development in complicated and dynamic physiological systems, but also serve as irreplaceable tools for developing and testing new therapies.  Shanghai Model Organisms Center offers a variety of mouse models of cancer to meet the needs of both academic and industry partners.

Mouse Models Expedite the Elucidation of AD Pathogenesis