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P53 CKO Mouse Model

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Our own-developed mouse model of p53 conditional knockout (p53-CKO) can be mated with mice carrying tissue-specific Cre expression to obtain mice with homozygous deletion of p53 in specific tissues or cells. These mice can be used for tumorigenesis and tumor mechanistic studies.

Pten CKO Mouse Model

Our own-developed mouse model of Pten conditional knockout (Pten-CKO) can be mated with mice carrying tissue-specific Cre expression to obtain mice with homozygous deletion of Pten in specific tissues or cells, thus avoiding the embryonic death caused by systemic and homozygous Pten knockout. Pten-CKO mice can be used to study tumorigenesis, anti-tumor targets, neurogenesis, glial differentiation and cerebellar development.

Applications of Animal Models

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The model animal has played an important role in the history of life sciences and medicine, with a wide range of application in biology, medicine, molecular biology, molecular genetics, immunology and other fields.

Customize your genetically engineered models

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The scientific team at Shanghai Model Organisms Center, Inc, comprising of seasoned molecular biologists and technicians, is dedicated to providing highly customizable, genetically engineered models to global researchers.

How to Verify Your Cre-lox Model

Nervous System

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The model of nerve injury induced by surgery or drugs can be used to study the mechanism of nerve injury and to evaluate drug efficacy.

Endocrinology and Metabolism

Diabetic mouse model type 2 diabetes mouse model

Long-term feeding of high-fat diets can cause obesity and increased fasting blood glucose in mice along with fat accumulation and insulin resistance in the body to mimic human type II diabetes.

Fibrosis

liver fibrosis model

The mouse liver fibrosis model can be generated by surgery or drug induction, which can be used to study the role of genes and proteins in the development of liver fibrosis, to explore the mechanisms underlying liver fibrosis, and to carry out drug efficacy evaluations.

Mouse

transgenic mice mouse model editing mouse

Mice have long been the prime choice for model organisms. In more than 100 years, mice have been widely used by researchers in the fields of physiology, pathology, pharmacology, toxicology, and behavioral science. With the establishment of gene targeting technology, many researchers have made their way to the Nobel Prize.

Animal Health

Animal Health Care

Shanghai Model Organisms Center (SMOC) provides you with model mice that have been raised under specific pathogen-free (SPF) barriers. Since obtaining AAALAC-accreditation in 2012, Shanghai Model Organisms Center Co., Ltd. has adhered to the standards outlined in the Guide for the Care and Use of Laboratory Animals (Guide). With an experienced team of veterinarians and researchers, advanced equipment, mature testing technologies and strict quality management system, SMOC guarantees consistent quality and is an ideal choice for your project.