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Enhancing the precision of genetic lineage tracing using dual recombinases

Model Organisms：小鼠 Product & Service：IR1, IR2, NR1, NR2, CAG-DreER, Tnni3-Dre, Tnnt2-Dre, Alb-CreER, CK19-Dre 和 Alb-DreER Research field：Genetic lineage tracing

谱系示踪 DeaLT-IR 双报告基因系统

Generation of a self‐cleaved inducible Cre recombinase for efficient temporal genetic manipulation

Model Organisms：Mouse Product & Service：Npr3-sCreER, Npr3-CreER, Col1a2-sCreER, Col1a2-CreER, and R26-LZLT Research field：cell lineages

A Suite of New Dre-recombinase Drivers Markedly Expands the Ability to Perform Intersectional Genetic Targeting

Model Organisms：Mouse Product & Service：Sox9-IRES-DreERT2;Pdgfb-(DreERT2-IRES-eGFP-wpre-polyA) Research field：lineage tracing

Harnessing the Power of the Cre-loxP System: Benefits, Challenges, and Applications

This webinar will introduce the Cre-loxP system, a powerful genetic tool that has revolutionized biological research by allowing for conditional gene knockout, knockdown, and overexpression. We will cover the history of the genetic recombination systems, discuss how they enable precise control of gene expression in specific cell types or at specific developmental stages, and present GenoBioTX’s genetically modified models utilizing this method.

What are genetically engineered mice?

mouse genome point mutation transgene

On Nature Genetics Prof. Bin Zhou's group used lineage-tracing mice produced by SMOC to investigate the role of bronchioalveolar stem cells

bronchioalveolar stem cells lung repair lung regeneration

Published on today's Nature Genetics, Prof. Bin Zhou's research group from Shanghai Institute of Biochemistry and Cell Biology revealed the bona fide role of bronchioalveolar stem cells (BASC) during lung repair and regeneration.

These Mice Are About to Go Viral Because of the Nobel Prize!

microRNA (miRNA) microRNA mouse models Nobel Prize microRNA discovery genetically engineered mice miRNA in gene regulation miRNA therapeutics miRNA in cancer research customized mouse models contract research organization (CRO) preclinical drug discovery

The 2024 Nobel Prize in Physiology or Medicine awarded to Victor Ambros and Gary Ruvkun for their discovery of microRNA (miRNA) highlights its revolutionary role in gene regulation and disease treatment. This article explores miRNA's impact on neuroscience, cancer, and cardiovascular research. GenoBioTX offers advanced microRNA mouse models and customized genetic solutions, empowering researchers with essential tools to drive innovation in miRNA studies and therapeutic developments.

What is an inbred strain?

inbreeding coefficient inbreeding depression FVB

Overcome the Hurdle to Generate High Affinity and Diversity Antibodies to Self- or High Homology Antigens

Join us for an insightful webinar discussing advanced methodologies for generating monoclonal antibodies. This session will cover traditional and innovative approaches, highlighting their advantages and challenges.

SMOC Launched U-HuDTMbase®, Inclusive Resource Library of Innovative Therapeutic Target-Humanized Mouse Models, to Accelerate Novel Drug Discovery

U-HuDTMbase® is composed of more than 600 therapeutic target-humanized mouse models, including multiple background strains, and has covered almost all commonly studied areas, such as oncology, metabolism, immunity, inflammation and more.