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Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium

Model Organisms：小鼠 Product & Service： Npr3-CreER、Wt1-CreER、Sox9-CreER 和 Nfatc1-2A-CreER Research field：Heart

遗传谱系示踪 心内膜弹性纤维增生症 TGFβ

Disruption of imprinting and aberrant embryo development in completely inbred embryonic stem cell-derived mice

Model Organisms：小鼠 Product & Service：- Research field：Model approach

DNA methylation embryo development epigenetic genome imprinting inbred ES cell

Join Our Webinar: Applications of Humanized Mouse Models in Preclinical Research

Humanized mouse models preclinical research targeted therapies webinar oncology drug development preclinical therapeutic advancements immune system models animal modeling services

Join GenoBioTX's webinar on July 25th to explore the latest advancements in humanized mouse models for preclinical research. Learn how these models are transforming targeted therapy development across various diseases. Featuring expert insights from Dr. Derek Reznik, discover the generation and application of humanized immune system models in oncology drug development. Don't miss this opportunity to enhance your knowledge in cutting-edge preclinical therapeutic advancements. Register now!

Is the recombination efficiency of Cre the same regardless of whether it is from the paternal or maternal inheritance?

paternal inheritance maternal inheritance Cre expression

Overcome the Hurdle to Generate High Affinity and Diversity Antibodies to Self- or High Homology Antigens

Join us for an insightful webinar discussing advanced methodologies for generating monoclonal antibodies. This session will cover traditional and innovative approaches, highlighting their advantages and challenges.

SMOC Launched U-HuDTMbase®, Inclusive Resource Library of Innovative Therapeutic Target-Humanized Mouse Models, to Accelerate Novel Drug Discovery

U-HuDTMbase® is composed of more than 600 therapeutic target-humanized mouse models, including multiple background strains, and has covered almost all commonly studied areas, such as oncology, metabolism, immunity, inflammation and more.

GEMM-Derived Allografts

Liver Cancer PDX Model

PDX PDX models Patient-derived Xenografts

Patient-derived Xenografts (PDX) are advanced preclinical oncology models for drug development. It offers a far better alternative for preclinical drug evaluation as compared to the conventional cell line-derived xenograft model.

Humanized Mice

NMG mice with human-derived CD34+ hematopoietic stem cells can be used for reconstruction of multi-lineage human immune cells, and represent effective model animals for studies on immuno-oncology and infectious diseases.

Humanized Mice

NMG and NMG-B2m mice transplanted with human-derived PBMC are suitable for short-term in vivo tests requiring mature T cell function, including studies on HIV infection, immuno-oncology and GvHD.