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A Suite of New Dre-recombinase Drivers Markedly Expands the Ability to Perform Intersectional Genetic Targeting

Model Organisms：Mouse Product & Service：Sox9-IRES-DreERT2;Pdgfb-(DreERT2-IRES-eGFP-wpre-polyA) Research field：lineage tracing

On Nature Genetics Prof. Bin Zhou's group used lineage-tracing mice produced by SMOC to investigate the role of bronchioalveolar stem cells

bronchioalveolar stem cells lung repair lung regeneration

Published on today's Nature Genetics, Prof. Bin Zhou's research group from Shanghai Institute of Biochemistry and Cell Biology revealed the bona fide role of bronchioalveolar stem cells (BASC) during lung repair and regeneration.

Harnessing the Power of the Cre-loxP System: Benefits, Challenges, and Applications

This webinar will introduce the Cre-loxP system, a powerful genetic tool that has revolutionized biological research by allowing for conditional gene knockout, knockdown, and overexpression. We will cover the history of the genetic recombination systems, discuss how they enable precise control of gene expression in specific cell types or at specific developmental stages, and present GenoBioTX’s genetically modified models utilizing this method.

These Mice Are About to Go Viral Because of the Nobel Prize!

microRNA (miRNA) microRNA mouse models Nobel Prize microRNA discovery genetically engineered mice miRNA in gene regulation miRNA therapeutics miRNA in cancer research customized mouse models contract research organization (CRO) preclinical drug discovery

The 2024 Nobel Prize in Physiology or Medicine awarded to Victor Ambros and Gary Ruvkun for their discovery of microRNA (miRNA) highlights its revolutionary role in gene regulation and disease treatment. This article explores miRNA's impact on neuroscience, cancer, and cardiovascular research. GenoBioTX offers advanced microRNA mouse models and customized genetic solutions, empowering researchers with essential tools to drive innovation in miRNA studies and therapeutic developments.

What are genetically engineered mice?

mouse genome point mutation transgene

What is an inbred strain?

inbreeding coefficient inbreeding depression FVB

Overcome the Hurdle to Generate High Affinity and Diversity Antibodies to Self- or High Homology Antigens

Join us for an insightful webinar discussing advanced methodologies for generating monoclonal antibodies. This session will cover traditional and innovative approaches, highlighting their advantages and challenges.

SMOC Launched U-HuDTMbase®, Inclusive Resource Library of Innovative Therapeutic Target-Humanized Mouse Models, to Accelerate Novel Drug Discovery

U-HuDTMbase® is composed of more than 600 therapeutic target-humanized mouse models, including multiple background strains, and has covered almost all commonly studied areas, such as oncology, metabolism, immunity, inflammation and more.

Join Our Webinar: Advanced Strategies in Genetically Modified Mice

Discover cutting-edge strategies and applications of genetically modified mice in biomedical research at our webinar on May 23rd, 2024. Register now for insights from industry expert Dongxiao Feng

Lineage tracing

lineage tracing genetic lineage tracing genetic fate mapping

Genetic lineage tracing is a commonly used and the most effective method for studying the origin and fate of specific cell types. The construction of genetically engineered mouse model is the most important step in the lineage tracing technique.