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What are genetically engineered mice?

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What is an inbred strain?

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SMOC Launched U-HuDTMbase®, Inclusive Resource Library of Innovative Therapeutic Target-Humanized Mouse Models, to Accelerate Novel Drug Discovery

U-HuDTMbase® is composed of more than 600 therapeutic target-humanized mouse models, including multiple background strains, and has covered almost all commonly studied areas, such as oncology, metabolism, immunity, inflammation and more.

On Nature Genetics Prof. Bin Zhou's group used lineage-tracing mice produced by SMOC to investigate the role of bronchioalveolar stem cells

bronchioalveolar stem cells lung repair lung regeneration

Published on today's Nature Genetics, Prof. Bin Zhou's research group from Shanghai Institute of Biochemistry and Cell Biology revealed the bona fide role of bronchioalveolar stem cells (BASC) during lung repair and regeneration.

Join Our Webinar: Advanced Strategies in Genetically Modified Mice

Discover cutting-edge strategies and applications of genetically modified mice in biomedical research at our webinar on May 23rd, 2024. Register now for insights from industry expert Dongxiao Feng

Services

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Shanghai Model Organisms offers a full range of model organism services, including model customization services, research-ready models, breeding, phenotyping and drug screening. Mouse, rat, zebrafish and C. elegans models are available to meet different research needs.

Gene Knockout

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Expedite your research with highly customizable, gene knockout mouse models that provide thorough insight into key genetic mechanisms.

Cancer Model

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The laboratory mouse is widely considered as a valid and affordable model organism for studying human disease. Mouse models of cancer not only enable researchers to understand the genetic basis of tumor development in complicated and dynamic physiological systems, but also serve as irreplaceable tools for developing and testing new therapies.  Shanghai Model Organisms Center offers a variety of mouse models of cancer to meet the needs of both academic and industry partners.

Overview of gene editing technology

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Mouse

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Mice have long been the prime choice for model organisms. In more than 100 years, mice have been widely used by researchers in the fields of physiology, pathology, pharmacology, toxicology, and behavioral science. With the establishment of gene targeting technology, many researchers have made their way to the Nobel Prize.