Genetically Modified Tumor Mouse Models

The genetically modified spontaneous tumor models are constructed by introducing targeted genetic alterations in mice to induce tumor formation. These models typically involve CRISPR/Cas9-mediated modifications of oncogenes or tumor suppressor genes, where either constitutive activation or conditional knockout of gene expression drives tumorigenesis through defined molecular pathways. SMOC has independently developed a variety of spontaneous tumor mouse models to support preclinical drug development.
GMM models of cancer
GMM-derived tumor allograft models

The table below lists strains of mice with genetically modified tumor mouse models. Click to visit the strain page for more information.

Cat. NO. Strain name Validation Data Strain State
NM-KI-190007 R26-CAG-LSL-hFGFR2-IRES-Luc-2A-EGFP Absence Embryo cryopreservation
NM-KI-190081 R26-CAG-LSL-hFGFR3*K562E-IRES-Luc-2A-EGFP Absence Embryo cryopreservation
NM-KI-190082 R26-CAG-LSL-hFGFR3*S249C-IRES-Luc-2A-EGFP Absence Embryo cryopreservation
NM-KI-190083 R26-CAG-LSL-hFGFR3-IRES-Luc-2A-EGFP Absence Embryo cryopreservation
NM-KI-190071 R26-CAG-LSL-hHER2*ex20ins-IRES-Luc-2A-EGFP Absence Sperm cryopreservation
NM-KI-190008 R26-CAG-LSL-hHER2-IRES-Luc-2A-EGFP Absence Sperm cryopreservation
NM-KI-190074 R26-CAG-LSL-hIDH1*R132H-IRES-Luc-2A-tdTomato Absence Embryo cryopreservation
NM-KI-190075 R26-CAG-LSL-hIDH2*R140Q-IRES-Luc-2A-tdTomato Absence Embryo cryopreservation
NM-KI-190076 R26-CAG-LSL-hIDH2*R172K-IRES-Luci-2A-tdTomato Absence Sperm cryopreservation
NM-KI-190077 R26-CAG-LSL-hNFE2L2*G81S-IRES-Luc-2A-tdTomato Absence Embryo cryopreservation
**Some mouse models require the use of AAV-Cre induction or breeding with other Cre mice to achieve the desired tumor phenotype
基于原发肿瘤小鼠的移植瘤小鼠模型
GMM Cell line-derived tumor allograft models

Primary cell lines for the establishment of tumor allograft models:

Cat. NO. Strain name Specimen Name Strain State

Case Studies on Efficacy Evaluation

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Fig. Growth of KPC mouse tumour cells inoculated into the liver, lung and pancreas of wild C57BL/6 mice.

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Fig. Evaluation of antitumour efficacy of cell lines derived from tumour masses in KPC mice (host mouse pairs are C57BL/6 mice). a. Efficacy tumourigenic curve, b. Efficacy body weight curve, c, photographs of tumours.

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Fig. Stk11/EGFP/Kras-LSL-G12D primary lung cancer mouse model can trigger lung cancer by AAV-CRE induction.

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Fig. Evaluation of anti-tumour efficacy of Stk11/EGFP/Kras-LSL-G12D tumour mass-derived cell line.

GMM tumor tissues-derived tumor allograft models

Case Studies on Efficacy Evaluation

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Fig. Homograft experiments of spontaneous hepatocellular carcinoma tumour blocks in H11-LSL-Myc/Rosa26-LSL-LuC-EGFP/Ab-Cre triple-positive mice. a. Tumour growth, b. Efficacy tumourigenicity curves, and c. Changes in efficacy body weight.

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