Genetically Modified Tumor Mouse Models

The genetically modified spontaneous tumor models are constructed by introducing targeted genetic alterations in mice to induce tumor formation. These models typically involve CRISPR/Cas9-mediated modifications of oncogenes or tumor suppressor genes, where either constitutive activation or conditional knockout of gene expression drives tumorigenesis through defined molecular pathways. SMOC has independently developed a variety of spontaneous tumor mouse models to support preclinical drug development.
GMM models of cancer
GMM-derived tumor allograft models

The table below lists strains of mice with genetically modified tumor mouse models. Click to visit the strain page for more information.

Cat. NO. Strain name Validation Data Strain State
NM-CKO-200014 Brca2-Flox Absence Sperm cryopreservation
NM-KI-190084 H11-CAG-LSL-Mycn-IRES-EGFP Absence Embryo cryopreservation
NM-KO-200637 Il10-KO(BALB/c) Absence Repository Live
NM-KI-220014 KPC(2) Absence Embryo cryopreservation
NM-KI-234804 KPC(3) Absence Repository Live
NM-CKO-200017 Nf2-Flox Absence Repository Live
NM-TG-225004 pMMTV-Jag1-Tg(Balb/c) Absence Sperm cryopreservation
NM-CKO-18004 Pten-Flox Absence Repository Live
NM-KO-18002 Pten-KO Absence Embryo cryopreservation
NM-KI-190127 R26-CAG-LSL-hBCR/ABL Absence Sperm cryopreservation
**Some mouse models require the use of AAV-Cre induction or breeding with other Cre mice to achieve the desired tumor phenotype
基于原发肿瘤小鼠的移植瘤小鼠模型
GMM Cell line-derived tumor allograft models

Primary cell lines for the establishment of tumor allograft models：

Cat. NO. Strain name Specimen Name Strain State

Case Studies on Efficacy Evaluation

Tumor model estabilished with the cell line derived KPC tumor

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Fig. Growth of KPC mouse tumour cells inoculated into the liver, lung and pancreas of wild C57BL/6 mice.

Efficacy evaluation of anti-tumour efficacy in tumor model estabilished with the cell line derived KPC tumor

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Fig. Evaluation of antitumour efficacy of cell lines derived from tumour masses in KPC mice (host mouse pairs are C57BL/6 mice). a. Efficacy tumourigenic curve, b. Efficacy body weight curve, c, photographs of tumours.

Efficacy evaluation of anti-tumour efficacy in tumor model estabilished with the cell line derived Stk11/EGFP/Kras-LSL-G12D tumor

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Fig. Stk11/EGFP/Kras-LSL-G12D primary lung cancer mouse model can trigger lung cancer by AAV-CRE induction.

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Fig. Evaluation of anti-tumour efficacy of Stk11/EGFP/Kras-LSL-G12D tumour mass-derived cell line.

GMM tumor tissues-derived tumor allograft models

Case Studies on Efficacy Evaluation

Efficacy evaluation of anti-tumour efficacy in tumor model estabilished with the tissue derived Alb-Cre-Tg/H11-CAG-LSL-Myc tumor

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Fig. Homograft experiments of spontaneous hepatocellular carcinoma tumour blocks in H11-LSL-Myc/Rosa26-LSL-LuC-EGFP/Ab-Cre triple-positive mice. a. Tumour growth, b. Efficacy tumourigenicity curves, and c. Changes in efficacy body weight.

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