Models

Conditional Knockouts

In the conditional knockout mouse model, the gene of interest is deleted only in selected cells, as determined by a tissue-specific promoter. Conditional knockout mice are usually generated using Cre-LoxP, Dre-Rox, or Flp-Frt recombination systems for permanent gene alterations in specific tissues. The targeted fragment to be knocked out is flanked by LoxP elements. Floxed mice are then bred with tissue-specific Cre or CreERT2 mice, and sequences between LoxP sites will be removed from the offspring’s genome in a spatial and/or temporal manner.

mouse
Strain Name:C57BL/6JSmo-Il12aem1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-2108334
mouse
Strain Name:C57BL/6JSmo-Il12bem1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-231940
mouse
Strain Name:C57BL/6Smoc-Il12rb1em1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
mouse
Strain Name:C57BL/6Smoc-Il12rb2em1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
mouse
Strain Name:C57BL/6JSmo-Il13em(flox)/Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-230200
mouse
Strain Name:C57BL/6JSmo-Il13tm1(flox)Il4tm1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-200169
Research Application:ERK signaling and development and the heterogeneity of the ILC family; related research on hematopoietic cell lineage and ERK signaling
mouse
Strain Name:C57BL/6Smoc-Il13ra1em1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD
mouse
Strain Name:C57BL/6JSmo-Il13ra2em1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-231325
mouse
Strain Name:C57BL/6JSmo-Il15em(flox)/Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-220626
mouse
Strain Name:C57BL/6JSmo-Il15raem1(flox)Smoc
Strain State:Repository Live | Cat. NO.:NM-CKO-205222
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