U-GEMMs

代谢心血管疾病模型

代谢心血管疾病包括2型糖尿病、心脏代谢紊乱、高脂血症、动脉粥样硬化、高血压等,这类慢性病严重影响人的生活质量,并会带来沉重的经济负担。南模生物自主构建了多种代谢心血管疾病模型小鼠,可助力代谢心血管疾病的基础研究和药物开发。

Mice
Strain Name:C57BL/6Smoc-Smad4tm1(flox)Smoc
Strain State:Repository Live | Cat. NO.:NM-CKO-18011
Disease Connection:osteogenesis imperfecta, squamous cell carcinoma, stomach cancer
Mice
Strain Name:C57BL/6Smoc-Trp53tm2(flox)Smoc
Strain State:Repository Live | Cat. NO.:NM-CKO-18005
Disease Connection:medulloblastoma, breast cancer, prostate cancer, central nervous system cancer, osteosarcoma, pancreatic carcinoma, malignant astrocytoma, thyroid gland carcinoma, ovarian cancer, urinary bladder cancer, alveolar rhabdomyosarcoma, glioblastoma, pancreatic ductal adenocarcinoma, squamous cell carcinoma, thyroid gland cancer, CHARGE syndrome, stomach cancer, invasive lobular carcinoma, endometrial cancer, hereditary breast ovarian cancer syndrome, pancreatic mucinous cystadenoma
Mice
Strain Name:C57BL/6Smoc-Trp53em5Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KO-191203
Disease Connection:medulloblastoma, malignant astrocytoma, neurofibromatosis, diffuse large B-cell lymphoma, Li-Fraumeni syndrome
Mice
Strain Name:C57BL/6Smoc-Trp53tm(LSL- R172H)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KI-220071
Research Application:Spontaneous Tumor
Mice
Strain Name:C57BL/6Smoc-Tsc2tm1(flox)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-CKO-2102032
Disease Connection:uterine fibroid, tuberous sclerosis
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