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Literature

Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome

Model Organisms：小鼠 Product & Service：- Research field：

Published date：2024-04-12 | References：Cell Reports

Literature

Preclinical characterization of Sintilimab, a fully human anti-PD-1 therapeutic monoclonal antibody for cancer

Model Organisms：Mouse Product & Service：PD-1 Research field：Cancer Immunotherapy

Published date：2018-08-17 | References：Antibody Therapeutics

Literature

Integrated multi-omics reveal gut microbiota-mediated bile acid metabolism alteration regulating immunotherapy...

Model Organisms：小鼠 Product & Service：- Research field：

Published date：2024-02-05 | References：Gut Microbes

Literature

The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype, promoting a favorable...

Model Organisms：小鼠 Product & Service：huHSC-(M-NSG) Research field：The therapeutic mechanism of immunotherapy for non-small cell lung cancer

Published date：2023-12-07 | References：Cellular & Molecular Immunology

Literature

IMT030122, A novel engineered EpCAM/CD3/4-1BB tri-specific antibody, enhances T-cell recruitment and demonstrates...

Model Organisms：小鼠 Product & Service：- Research field：

Published date：2024-06-14 | References：INTERNATIONAL IMMUNOPHARMACOLOGY

Literature

Transcriptional analysis of immune-related genes in dendritic cells from hepatitis B surface antigen (HBsAg)-positive...

Model Organisms：小鼠 Product & Service：HBV-Tg Research field：hepatitis B

Published date：2011-01-01 | References：Journal of Medical Virology

Pages
Pages

SMOC Launched U-HuDTMbase®, Inclusive Resource Library of Innovative Therapeutic Target-Humanized Mouse Models, to Accelerate Novel Drug Discovery

U-HuDTMbase® is composed of more than 600 therapeutic target-humanized mouse models, including multiple background strains, and has covered almost all commonly studied areas, such as oncology, metabolism, immunity, inflammation and more.

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Aging and Longevity Research

Humans have always been fascinated with the study of aging. Despite experiencing thousands of years of civilization, we have yet to clearly identify the mechanisms of aging. Either from the perspective of drug development or genetic research, the study of aging is undoubtedly a worthy cause.

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