Aging and Longevity Research
C. elegans has about 20,000 genes and its homologues have been identified for 60–80% of human genes. The classic signaling pathway affecting aging - insulin signaling pathway - was first discovered in C. elegans. Other signaling pathways that influence aging, such as FOXO signals, TOR signals, sirtuin signals, dietary restrictions are also conserved in humans. In addition, C. elegans has a short life span of 2-3 weeks under normal temperature conditions, making it a suitable choice for the study of phenotypes and mechanisms of aging.
Our services include:
Detection of gene or drug effects on the lifespan of C. elegans and uncovering potential anti-aging genes or drugs.
Studies on gene or drug effects using genetic methods, including FOXO signaling pathways, insulin-like signals, germline signals, dietary restriction signals and TOR signals etc.
Detection of free radical levels, muscle degradation, gene expression levels, daf-16 nuclear localization levels and mobility levels in C. elegans.
Published articles
1. Wu M, Kang X, Wang Q, Zhou C, Mohan C, Peng A.Regulator of G protein signaling-1 modulates paraquat-induced oxidative stress and longevity via the insulin like signaling pathway in Caenorhabditis elegans.Toxicol Lett. 2017 May 5;273:97-105. doi: 10.1016/j.toxlet.2017.03.027. Epub 2017 Mar 31.
2. Fei T, Fei J, Huang F, Xie T, Xu J, Zhou Y, Yang P.The anti-aging and anti-oxidation effects of tea water extract in Caenorhabditis elegans.Exp Gerontol. 2017 Oct 15;97:89-96.
3. Ping Yang，Ruilin Sun,Minghui Yao,Weidong Chen,Zhugang Wang,Jian Fei*.A C-terminal trun-cated mutation of spr-3 gene extends life span in Caenorhabditis elegans，Acta Biochim Biophys Sin (Shanghai). 2013 Jul;45(7):540-8
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