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Pharmacodynamics Analysis & Evaluation

Based on the U-GEMM repository, the pharmacodynamics evaluation service from Shanghai Model Organisms can conduct main pharmacodynamics study on the drugs for anti-inflammatory-immunity, antineoplastic, cardiovascular system, respiratory system and metabolic diseases,etc, satisfy the study requirements of different layers of in vivo experiments, mechanism investigation and molecular biological study, and confirm the effectiveness and safety of new drug(s).

Pten CKO Mouse Model

Our own-developed mouse model of Pten conditional knockout (Pten-CKO) can be mated with mice carrying tissue-specific Cre expression to obtain mice with homozygous deletion of Pten in specific tissues or cells, thus avoiding the embryonic death caused by systemic and homozygous Pten knockout. Pten-CKO mice can be used to study tumorigenesis, anti-tumor targets, neurogenesis, glial differentiation and cerebellar development.

Evaluating the Efficacy of Tumor-targeted Antibody in vivo

immunotherapy immune checkpoint immune checkpoint genes

As the most frequently used animal model, mice have been widely applied in the evaluation of drug efficacy. However, the human immune checkpoint genes only share ~60% identity with their murine counterparts. Thus antibodies that recognize human proteins do not necessarily interact with murine proteins, making it inappropriate to use wild type mice for evaluating the in vivo efficacy of human-specific antibody. The humanized immune checkpoint mouse models (Immune-Hu models), which were independently developed by Shanghai Model Organisms Center, are ideal models to evaluate the efficacy of anti-tumor antibody therapy.

薬効の分析と評価

上海南方モデル動物バイオテクノロジー株式会社（Shanghai Model Organisms Center, Inc）の薬力学的評価サービスは、二十年の業界経験を積み重ねて、自社開発のU-GEMM®モデルマウスリソースライブラリーを利用して、抗炎免疫、抗腫瘍、心臓血管系、呼吸器系、代謝性疾患など薬物のスクリーニングをする為に、研究者様の求めに応じて 、in vivo 実験、メカニズムの検討、分子生物学研究などの異なるレベルの研究ニーズを満足し、新薬の有効性と安全性を明らかにし、国内外の製薬会社、生物医薬研究機関、新薬開発センター、大学の新薬開発機関などに、専門的な薬力学的評価サービスを提供しております。

약물 효과 분석 및 평가

Shanghai Model Organisms Center, Inc.(사)는 약물 효과 평가 서비스는 U-GEMMs 리소스 라이브러리를 기반으로 하여 항염 면역, 항종양, 심혈관계, 호흡계, 대사성 질병 등 약물의 주요 약력학 연구를 수행할 수 있으며, 체내 실험, 메커니즘 검토 및 분자생물학 연구 등 서로 다른 수준의 연구 수요를 충족시켜 신약의 유효성과 안전성을 확립하고 국내외의 제약업체, 생물의학연구소, 신약개발센터, 고등교육기관의 신약 연구개발 기관 등에 전문적인 약력학 평가 서비스를 제공합니다.

Cancer Model

research on cancer cancer model mouse models of cancer

The laboratory mouse is widely considered as a valid and affordable model organism for studying human disease. Mouse models of cancer not only enable researchers to understand the genetic basis of tumor development in complicated and dynamic physiological systems, but also serve as irreplaceable tools for developing and testing new therapies.  Shanghai Model Organisms Center offers a variety of mouse models of cancer to meet the needs of both academic and industry partners.

Integrated Service for Antibody Discovery from Target to PCC

Non-GLP Toxicology Service

Mouse models for cancer research

Tumor bearing Mouse DEN model PDX model CDX model

Shanghai Model Organisms Center provides multiple types of tumor-bearing mouse models for cancer research and drug efficacy testing, including cell line-derived xenograft model (CDX) and patient-derived xenograft model (PDX). While PDX models better reflect the heterogeneity and diversity of human cancers, CDX models allow researchers to advance their pre-clinical drug development in a cost- and time-efficient manner.

Liver Cancer PDX Model

PDX PDX models Patient-derived Xenografts

Patient-derived Xenografts (PDX) are advanced preclinical oncology models for drug development. It offers a far better alternative for preclinical drug evaluation as compared to the conventional cell line-derived xenograft model.