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Literature

Preclinical characterization of Sintilimab, a fully human anti-PD-1 therapeutic monoclonal antibody for cancer

Model Organisms：Mouse Product & Service：PD-1 Research field：Cancer Immunotherapy

Published date：2018-08-17 | References：Antibody Therapeutics

Literature

Integrated multi-omics reveal gut microbiota-mediated bile acid metabolism alteration regulating immunotherapy...

Model Organisms：小鼠 Product & Service：- Research field：

Published date：2024-02-05 | References：Gut Microbes

Literature

The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype, promoting a favorable...

Model Organisms：小鼠 Product & Service：huHSC-(M-NSG) Research field：The therapeutic mechanism of immunotherapy for non-small cell lung cancer

Published date：2023-12-07 | References：Cellular & Molecular Immunology

Literature

IMT030122, A novel engineered EpCAM/CD3/4-1BB tri-specific antibody, enhances T-cell recruitment and demonstrates...

Model Organisms：小鼠 Product & Service：- Research field：

Published date：2024-06-14 | References：INTERNATIONAL IMMUNOPHARMACOLOGY

Literature

Transcriptional analysis of immune-related genes in dendritic cells from hepatitis B surface antigen (HBsAg)-positive...

Model Organisms：小鼠 Product & Service：HBV-Tg Research field：hepatitis B

Published date：2011-01-01 | References：Journal of Medical Virology

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SMOC Launched U-HuDTMbase®, Inclusive Resource Library of Innovative Therapeutic Target-Humanized Mouse Models, to Accelerate Novel Drug Discovery

U-HuDTMbase® is composed of more than 600 therapeutic target-humanized mouse models, including multiple background strains, and has covered almost all commonly studied areas, such as oncology, metabolism, immunity, inflammation and more.

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Aging and Longevity Research

Humans have always been fascinated with the study of aging. Despite experiencing thousands of years of civilization, we have yet to clearly identify the mechanisms of aging. Either from the perspective of drug development or genetic research, the study of aging is undoubtedly a worthy cause.

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Drug Screening

drug screening high throughput screening for drug discovery

With a comprehensive model organisms service platform that generates the mouse, zebrafish and C. elegans models, Shanghai Model Organisms enables high-throughput drug screening as well as the evaluation and research on drug efficacy, thus accelerating drug development and achieving greater accuracy in the prediction of in vivo interactions.

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