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Single-Cell RNA-Seq of the Developing Cardiac Outflow Tract Reveals Convergent Development of the Vascular Smooth...

Model Organisms：Mouse Product & Service：H11-(CAG-RSR-tdTomato) Research field：Heart

Long noncoding RNA UC.98 stabilizes atherosclerotic plaques by promoting the proliferation and adhesive capacity in...

Model Organisms：Mouse Product & Service：LDLR;GHSR Research field：atherosclerosis

atherosclerosis

Single-Cell RNA-Seq of the Developing Cardiac Outflow Tract Reveals Convergent Development of the Vascular Smooth...

Model Organisms：小鼠 Product & Service：H11-CAG-RSR-tdTomato Research field：Cardiac outflow tract

Targeting long noncoding RNA-AQP4-AS1 for the treatment of retinal neurovascular dysfunction in diabetes mellitus

Model Organisms：小鼠 Product & Service：Aqp4-KO Research field：Diabetic retinopathy

Knockdown of ecdysis-triggering hormone gene with a binary UAS/GAL4 RNA interference system leads to lethal ecdysis...

Model Organisms：家蚕 Product & Service：ETH Research field：Development

ecdysis-triggering hormone UAS/GAL4 system transgenic silkworm

CKO mice developed by SMOC supported the identification of a novel lncRNA that regulates dendritic cell migration and the corresponding immune response

CKO mice lncRNA dendritic cell

These Mice Are About to Go Viral Because of the Nobel Prize!

microRNA (miRNA) microRNA mouse models Nobel Prize microRNA discovery genetically engineered mice miRNA in gene regulation miRNA therapeutics miRNA in cancer research customized mouse models contract research organization (CRO) preclinical drug discovery

The 2024 Nobel Prize in Physiology or Medicine awarded to Victor Ambros and Gary Ruvkun for their discovery of microRNA (miRNA) highlights its revolutionary role in gene regulation and disease treatment. This article explores miRNA's impact on neuroscience, cancer, and cardiovascular research. GenoBioTX offers advanced microRNA mouse models and customized genetic solutions, empowering researchers with essential tools to drive innovation in miRNA studies and therapeutic developments.

Gene Expression/Protein Analysis

protein expression analysis Gene expression analysis

Shanghai Model Organisms provides high-quality gene and protein expression analysis services, including RT-PCR, real time PCR, and Western blot, with accurate experimental results that can be used for publication.

Osteoporosis

osteoporosis gene osteoporosis diseases Tnfrsf11b

Tnfrsf11b (Opg) knockout mice were generated through homologous recombination and supplied by Shanghai Research Center for Model Organisms. This mouse model, which is referred to as the "osteoporotic mouse", shows a typical phenotype of osteoporosis and arterial calcification, and Therefore, this animal model is ideal for drug screening and evaluation for the treatment of "human osteoporosis", in gene therapy of osteoporosis, as well as in the research on the mechanisms of interaction between osteoclasts and osteoblasts.

Services

genetic engineering genetic animals genetic engineering examples

Shanghai Model Organisms offers a full range of model organism services, including model customization services, research-ready models, breeding, phenotyping and drug screening. Mouse, rat, zebrafish and C. elegans models are available to meet different research needs.