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hCD24-Flox

Strain Name：C57BL/6Smoc-Cd24a^{em1(hCD24-flox)Smoc}
Strain State：Repository Live | Cat. NO.：NM-HU-231034

The endogenous mouse Cd24a exon2 was replaced by floxed humanized CD24 exon2.

hCD81/hOCLN

Strain Name：C57BL/6Smoc-Cd81^em1(hCD81)Ocln^em1(hOCLN)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000107

These mice are obtained through breeding of two single gene humanized mice.

hIL4/hIL4R

Strain Name：C57BL/6Smoc-Il4^tm3(hIL4)Il4ra^{tm1(hIL4R)Smoc}
Strain State：Repository Live | Cat. NO.：NM-HU-2000106

These mice are obtained through breeding of two single gene humanized mice.

hTIGIT/hPVR

Strain Name：C57BL/6Smoc-Tigit^em1(hTIGIT)Pvr^em1(hPVR)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000091

These mice are obtained through breeding of two single gene humanized mice.

R26-pAPOE-hCYP3A4(FVB)

Strain Name：FVB-Gt(ROSA)26Sor^{em1(pAPOE-CYP3A4)Smoc}
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18032

This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the liver-specific APOE promoter into the mouse Rosa26 site, which can be used to obtain liver-expressed CYP3A4 humanized model after mating with the Cyp3a13 gene and other Cyp3a family gene knockout mice. This model can be used with NM-KI-18033 mice which has gut-specific expression of human CYP3A4 to compare the contribution of intestinal versus hepatic metabolism to the biotransformation of a test article.

R26-pVillin1-hCYP3A4-IRES-tdTomato(FVB)

Strain Name：FVB-Gt(ROSA)26Sor^{em1(Gut-CYP3A4-IRES-tdTomato)Smoc}
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18033

Intestinal expression of the CYP3A enzyme in the human body can cause significant intestinal metabolism of the compound, resulting in impaired drug absorption. This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the Villin1 promoter together with the IRES-tdTomato reporter gene into mosue Rosa26 site, which can be crossed with the Cyp3a13 gene knockout and other Cyp3a family genes knockout mice to obtain intestinal-expressed CYP3A4 humanized mouse model in order to determine the contribution of intestinal metabolism to the absorption and distribution of test article.

MC38-OVA-luc

Strain Name：MC38-Igs2em1(OVA-Luc)/Smoc
Strain State ： Validation of target gene expression completed |  Cat. NO.：NM-S13-TM56

Humanized cell

This MC38 cell line harbors chicken OVA expression cassette.

A20-hCD47

Strain Name：A20-Cd47^{em1(hCD47)Smoc}
Strain State ： Validation of tumorigenic capacity completed |  Cat. NO.：NM-S26A-TM01

Humanized cell

The endogenous mouse Cd47 gene was replaced by human CD47 gene.

MC38-hCD133

Strain Name：MC38-Igs2^{em1(hCD133)Smoc}
Strain State ： Validation of target gene expression completed |  Cat. NO.：NM-S13-TM24

Humanized cell

A CD133 expression cassette was knocked into the H11 locus.

CT26-hPVR

Strain Name：CT26-Pvr^{em1(hPVR)Smoc}
Strain State ： Construction |  Cat. NO.：NM-S24A-TM06

Humanized cell

The endogenous mouse Pvr gene was replaced by human PVR gene.